Ungureanu Loredana Beatrice, Ghiciuc Cristina Mihaela, Amalinei Cornelia, Ungureanu Carmen, Petrovici Cristina Gabriela, Stănescu Raluca Ștefania
Morphopathology, Department of Morpho-Functional Sciences I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
Pharmacology, Clinical Pharmacology and Algeziology, Department of Morpho-Functional Sciences II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
Biomedicines. 2024 Aug 10;12(8):1820. doi: 10.3390/biomedicines12081820.
Formaldehyde induces oxidative stress and is carcinogenic, particularly squamous cell carcinoma of the nasopharyngeal area. Around us, in exhaust gases, cigarette smoke, and various industrial products, FA primarily affects the respiratory tract and other organs like the cornea, liver, kidneys, brain, and cardiovascular system. This study aims to determine if antioxidants can mitigate FA's harmful effects.
Several databases, including PubMed, Science Direct, Springer, and Wiley, were systematically searched. Research publications on antioxidants mitigating FA-induced oxidative damage were included, but reviews and articles lacking complete texts were excluded. SYRCLE's risk of bias tool for animal studies has been used. Tables were used for data synthesis. Out of 8790 articles, 35 publications detailing tissue homogenate for biochemical analysis, standard hematoxylin-eosin staining, and immunohistochemistry markers for histopathological and immunohistochemical diagnosis were selected. Most studies were case-control studies, utilizing rat or mouse models. Additionally, one cohort study on industrial workers was analyzed.
Antioxidants, including plant extracts, vitamins, and pigments, can prevent or heal FA-induced lesions. However, human studies, particularly biopsies, remain challenging, and animal trials are limited. Further research is needed to confirm FA's long-term effects and optimize antioxidant dosages.
甲醛会引发氧化应激且具有致癌性，尤其是对鼻咽部的鳞状细胞癌。在我们周围，废气、香烟烟雾以及各类工业产品中含有的甲醛，主要会影响呼吸道以及其他器官，如角膜、肝脏、肾脏、大脑和心血管系统。本研究旨在确定抗氧化剂是否能够减轻甲醛的有害影响。
系统检索了包括PubMed、Science Direct、Springer和Wiley在内的多个数据库。纳入了关于抗氧化剂减轻甲醛诱导的氧化损伤的研究出版物，但排除了综述和缺乏全文的文章。使用了SYRCLE动物研究偏倚风险工具。通过表格进行数据综合。在8790篇文章中，选取了35篇详细介绍用于生化分析的组织匀浆、标准苏木精-伊红染色以及用于组织病理学和免疫组化诊断的免疫组化标志物的出版物。大多数研究为病例对照研究，采用大鼠或小鼠模型。此外，还分析了一项针对产业工人的队列研究。
包括植物提取物、维生素和色素在内的抗氧化剂能够预防或治愈甲醛诱导的损伤。然而，人体研究，尤其是活检，仍然具有挑战性，动物试验也较为有限。需要进一步研究以确认甲醛的长期影响并优化抗氧化剂剂量。
