Ye Ksheeraja, Pius Chris Diana
Department of Ophthalmology, Ms Ramaiah Medical College Hospital, Bangalore, India.
Beyoglu Eye J. 2023 Sep 13;8(3):221-225. doi: 10.14744/bej.2023.03274. eCollection 2023.
Wernicke's encephalopathy (WE) is a condition resulting from thiamine deficiency and has been linked to conditions such as hyperemesis gravidarum, anorexia nervosa, hemodialysis, and chronic alcoholism. The aim of the report is to outline the ocular manifestations of WE. We present the case of a 33-year-old woman, who presented in her second trimester of pregnancy with persistent vomiting, nystagmus, ataxia, global confusion as well as hypotonia, and tremors. She was subsequently diagnosed with WE complicating pregnancy. Ophthalmoscopy showed asymmetric superficial retinal hemorrhages at the peripapillary area in both eyes with associated retinal exudates. On treatment with thiamine supplementation, her systemic condition as well as ocular symptoms resolved. This is a rare case outlining the ocular manifestations of WE. This condition may cause serious, lasting neurologic impairments or death if not properly treated. Only 50% of these pregnancies end in the delivery of healthy offspring. Early diagnosis and treatment of these cases can prevent avertable consequences.
韦尼克脑病（WE）是一种由硫胺素缺乏引起的疾病，与妊娠剧吐、神经性厌食症、血液透析和慢性酒精中毒等病症有关。本报告的目的是概述韦尼克脑病的眼部表现。我们报告一例33岁女性病例，该患者在妊娠中期出现持续呕吐、眼球震颤、共济失调、意识模糊以及肌张力减退和震颤。她随后被诊断为妊娠合并韦尼克脑病。眼底检查显示双眼视乳头周围区域不对称性浅表视网膜出血，并伴有视网膜渗出。补充硫胺素治疗后，她的全身状况以及眼部症状均得到缓解。这是一例罕见的病例，概述了韦尼克脑病的眼部表现。如果治疗不当，这种疾病可能会导致严重的、持久的神经功能损害甚至死亡。这些妊娠中只有50%能产下健康后代。对这些病例进行早期诊断和治疗可以避免可避免的后果。
