Elhadidy Tamer, Abdelwahab Heba Wagih, Shahin Doaa, Hewidy Asem, Khashaba Eman, Elmorsey Rehab Ahmad, Abo El Kheir Nermin, Eid Elsayed A, El-Mesery Ahmed, Elmaria Marwa O
Chest Medicine, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia Governorate, 35516, Egypt.
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Dakahlia Governorate, 35516, Egypt.
F1000Res. 2023 Aug 29;12:793. doi: 10.12688/f1000research.134565.2. eCollection 2023.
COVID-19 is a global pandemic that has affected millions of people all over the world since 2019. Infection with COVID-19 initiates a humoral immune response that produces antibodies against specific viral antigens, which in turn is supposed to provide immunity against reinfection for a period of time. The aim of this research was to study the kinetics of IgM and IgG antibodies against SARS-CoV-2. One hundred and seventeen post-COVID-19 participants were enrolled in the study. Qualitative assessment of IgM and IgG antibodies over six months (three visits) post recovery was conducted. The current study revealed a significant reduction in IgM and IgG titers between the first and second visits (p <0.001). After six months, the antibody titer had declined by 78.8% from the first visit for IgM and by 49.2% for IgG antibodies. Regarding younger age and male sex, statistically significant persistence of IgM antibodies was noticed at the six months follow up. Also, statistically significant persistent IgG immunity was found in male patients and diabetics by the end of the six months follow up. We observed a significant waning of IgM and IgG titers over a period of six months follow up.. The persistence of positive IgM and IgG antibodies by the end of six months was variable due to differences in age, gender and presence of diabetes mellitus.
2019年以来，新冠病毒病（COVID-19）已成为一场全球大流行疾病，影响了世界各地数百万人。感染新冠病毒病会引发体液免疫反应，产生针对特定病毒抗原的抗体，进而在一段时间内提供针对再次感染的免疫力。本研究的目的是研究针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的IgM和IgG抗体的动力学。117名新冠病毒病康复者参与了该研究。对康复后六个月（三次随访）内的IgM和IgG抗体进行了定性评估。当前研究显示，第一次和第二次随访之间，IgM和IgG滴度显著降低（p<0.001）。六个月后，IgM抗体滴度较第一次随访下降了78.8%，IgG抗体下降了49.2%。在六个月随访中，对于较年轻年龄组和男性，IgM抗体存在统计学上显著的持续存在情况。此外，在六个月随访结束时，男性患者和糖尿病患者中发现了具有统计学意义的持续IgG免疫力。在六个月的随访期内，我们观察到IgM和IgG滴度显著下降。由于年龄、性别和糖尿病患病情况的差异，六个月结束时IgM和IgG抗体阳性的持续情况各不相同。
