The syndrome of anticholinergic intoxication.

Over 600 compounds, including prescription and over-the-counter medications, may cause anticholinergic toxicity. Diagnosis of this potentially fatal condition rests on a detailed history and observation of peripheral and central anticholinergic signs. While supportive therapy is sufficient in most patients, some require treatment with physostigmine. Patient education, judicious drug selection and regular reviews of patients' medications will reduce the risk of anticholinergic toxicity.