Anderson C B, Sicard G A, Etheredge E E
Transplant Proc. 1979 Mar;11(1):482-5.
This study indicates that (1) ATN adversely affects long-term allograft survival but not patient survival, (2) in patients with delayed function the duration of ATN does not influence allograft survival, (3) ATN kidneys with good recovery (SCR less than 3.0) do as well as immediate-function kidneys, (4) poor recovery from ATN (SCR greater than 3.0) is associated with poor long-term allograft survival and may be the result of allograft rejection during ATN, since analysis of multiple characteristics at the time of transplantation failed to discern any difference between the good- and poor-recovery groups, and (5) there are no reliable pretransplant indicators of those kidneys that will never function or be in the poorly recovered group.
(1)急性肾小管坏死(ATN)对移植肾长期存活有不利影响,但对患者生存率无影响;(2)在移植肾功能延迟恢复的患者中,ATN的持续时间不影响移植肾存活;(3)恢复良好(血清肌酐清除率[SCR]小于3.0)的ATN肾与立即恢复功能的移植肾效果相同;(4)ATN恢复不佳(SCR大于3.0)与移植肾长期存活不良相关,可能是ATN期间移植肾排斥反应的结果,因为移植时对多个特征的分析未能发现恢复良好组与恢复不佳组之间存在任何差异;(5)对于那些永远无法恢复功能或属于恢复不佳组的肾,没有可靠的移植前指标。