Bedrick A E, Ramaswamy G, Tchertkoff V
Am J Clin Pathol. 1986 Nov;86(5):637-40. doi: 10.1093/ajcp/86.5.637.
Histochemical tests for copper, iron, and zinc revealed their presence in the stratum germinativum of normal skin and skin from which an early melanoma and basal cell and squamous cell carcinomas originated. However, only copper was seen in invasive cells of basal and squamous cell carcinomas originating from skin. The normal oral mucous membrane was free of copper, iron, and zinc, but cells of invasive squamous carcinoma originating from the oral mucous membrane contained copper. The fluorescent brightening agent, applied as a counterstain, aided in the location of the specimen.
对铜、铁和锌进行的组织化学测试显示，它们存在于正常皮肤、早期黑色素瘤、基底细胞癌和鳞状细胞癌起源处皮肤的生发层中。然而，仅在源自皮肤的基底细胞癌和鳞状细胞癌的浸润细胞中发现了铜。正常口腔黏膜不含铜、铁和锌，但源自口腔黏膜的浸润性鳞状细胞癌的细胞含有铜。用作复染剂的荧光增白剂有助于标本的定位。
