Gorodetsky R, Sheskin J, Weinreb A
Int J Dermatol. 1986 Sep;25(7):440-5. doi: 10.1111/j.1365-4362.1986.tb03449.x.
The concentrations of zinc (Zn), copper (Cu), and iron (Fe) in the skin have been noninvasively determined in vivo by diagnostic x-ray spectrometry. The skin of healthy controls was divided into two major groups based upon the distribution of the concentrations of these elements. In the face and upper neck, the following wet weight concentrations were recorded: Fe, 14.2 +/- 3.3 ppm; Cu, 1.3 +/- 0.3 ppm; and Zn, 6.7 +/- 1.1 ppm. In the chest, abdomen, arm, axilla, and lower neck, the concentrations of these elements were as follows: Fe, 10.2 +/- 2.5 ppm; Cu, 0.8 +/- 0.3 ppm; and Zn, 4.5 +/- 1.7 ppm. In most lesions of solar dermatitis, solar keratosis, basal and squamous cell carcinomas, variable elevations of Zn and Fe (up to significant levels) were recorded in most of the contralateral, apparently uninvolved skin. In the majority of pigmented nevi and malignant melanomas, the levels of Fe and Zn were elevated. In some of these, the Cu concentration also was increased.
通过诊断性X射线光谱法已在体内对皮肤中的锌（Zn）、铜（Cu）和铁（Fe）浓度进行了无创测定。根据这些元素浓度的分布，将健康对照者的皮肤分为两大组。在面部和上颈部，记录到以下湿重浓度：铁，14.2±3.3 ppm；铜，1.3±0.3 ppm；锌，6.7±1.1 ppm。在胸部、腹部、手臂、腋窝和下颈部，这些元素的浓度如下：铁，10.2±2.5 ppm；铜，0.8±0.3 ppm；锌，4.5±1.7 ppm。在大多数日光性皮炎、日光性角化病、基底细胞癌和鳞状细胞癌病变中，在大多数对侧明显未受累的皮肤中记录到锌和铁有不同程度的升高（高达显著水平）。在大多数色素痣和恶性黑色素瘤中，铁和锌的水平升高。其中一些病例中，铜的浓度也有所增加。
