Löning T, Viac J, Caselitz J, Thivolet J, Otto H F, Seifert G
Pathol Res Pract. 1982;175(2-3):256-65. doi: 10.1016/S0344-0338(82)80112-X.
Antibodies against different fractions of keratins can be helpful in various fields of special pathology. Antibodies against "small" and "large" keratins permit to evaluate epithelial maturation in skin and oral mucosa. In addition, disturbances of keratinization during inflammatory processes and malignant transformation can be analyzed. The main application of antibodies against the entire fractions of keratins is the detection of the epithelial nature of a neoplasm. By this tool, particular problems in surgical pathology concerning differential diagnosis can be handled in an easier way. Among the different tissues and their neoplasms, examples of the analysis of thymus tumours and salivary gland tumours are presented. Immunoreactivity with keratin antibodies depends crucially on tissue processing. In the normal diagnostic procedure, good results are regularly obtained if cryostat or Bouin-fixed paraffin-embedded sections are used.
针对不同角蛋白组分的抗体在特殊病理学的各个领域可能会有所帮助。针对“小”角蛋白和“大”角蛋白的抗体有助于评估皮肤和口腔黏膜中的上皮细胞成熟情况。此外，还可以分析炎症过程和恶性转化过程中的角化紊乱情况。针对整个角蛋白组分的抗体的主要应用是检测肿瘤的上皮性质。通过这个工具，可以更轻松地处理外科病理学中有关鉴别诊断的特定问题。在不同的组织及其肿瘤中，给出了胸腺肿瘤和唾液腺肿瘤分析的示例。角蛋白抗体的免疫反应性在很大程度上取决于组织处理。在正常诊断过程中，如果使用冷冻切片机或经Bouin固定的石蜡包埋切片，通常会获得良好的结果。
