Department of Industrial Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA, United States of America.
Department of Mechanical Engineering and Materials Science, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA, United States of America.
Nanotechnology. 2023 Oct 27;35(2). doi: 10.1088/1361-6528/acfe16.
The morphology of regular and uniform arrays of black silicon structures was evaluated for bactericidal efficacy against gram-positive, non-motile(). In this study, uniform and regular arrays of black silicon structures were fabricated using nanosphere lithography and deep reactive ion etching. The effects of nanomorphology on bacterial killing were systematically evaluated using silicon nanostructures with pitches ranging from 300 to 1400 nm pitch on spherical cocci approximately 500 to 1000 nm in diameter. Our results show that nanostructure morphology factors such as height and roughness do not directly determine bactericidal efficacy. Instead, the spacing between nanostructures plays a crucial role in determining how bacteria are stretched and lysed. Nanostructures with smaller pitches are more effective at killing bacteria, and an 82 ± 3% enhancement in bactericidal efficacy was observed for 300 nm pitch nanoneedles surface compared to the flat control substrates.
我们评估了规则和均匀排列的黑硅结构形态对革兰氏阳性、非运动性（）的杀菌效果。在这项研究中，使用纳米球光刻和深反应离子刻蚀技术制备了均匀和规则排列的黑硅结构。通过使用直径约为 500 至 1000nm 的球形球菌上的间距为 300 至 1400nm 的硅纳米结构，系统地评估了纳米形貌对细菌杀伤的影响。我们的结果表明，纳米结构形态因素（如高度和粗糙度）并不能直接决定杀菌效果。相反，纳米结构之间的间距在决定细菌如何被拉伸和裂解方面起着至关重要的作用。较小间距的纳米结构在杀菌方面更有效，与平面对照基底相比，300nm 间距纳米针表面的杀菌效果提高了 82±3%。
