Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL, 32610, USA; Center for Environmental and Human Toxicology, University of Florida, FL, 32608, USA.
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA.
Food Chem Toxicol. 2023 Nov;181:114062. doi: 10.1016/j.fct.2023.114062. Epub 2023 Sep 26.
Humans can be exposed to per- and polyfluoroalkyl substances (PFAS) through dietary intake from milk and edible tissues from food animals. This study developed a physiologically based pharmacokinetic (PBPK) model to predict tissue and milk residues and estimate withdrawal intervals (WDIs) for multiple PFAS including PFOA, PFOS and PFHxS in beef cattle and lactating dairy cows. Results showed that model predictions were mostly within a two-fold factor of experimental data for plasma, tissues, and milk with an estimated coefficient of determination (R) of >0.95. The predicted muscle WDIs for beef cattle were <1 day for PFOA, 449 days for PFOS, and 69 days for PFHxS, while the predicted milk WDIs in dairy cows were <1 day for PFOA, 1345 days for PFOS, and zero day for PFHxS following a high environmental exposure scenario (e.g., 49.3, 193, and 161 ng/kg/day for PFOA, PFOS, and PFHxS, respectively, for beef cattle for 2 years). The model was converted to a web-based interactive generic PBPK (igPBPK) platform to provide a user-friendly dashboard for predictions of tissue and milk WDIs for PFAS in cattle. This model serves as a foundation for extrapolation to other PFAS compounds to improve safety assessment of cattle-derived food products.
人类可以通过食用来自食品动物的奶和可食用组织摄入全氟和多氟烷基物质（PFAS）。本研究开发了一个基于生理学的药代动力学（PBPK）模型，用于预测多种 PFAS（包括 PFOA、PFOS 和 PFHxS）在肉牛和泌乳奶牛中的组织和奶残留，并估计其停药间隔（WDI）。结果表明，模型预测与实验数据相比，血浆、组织和奶中的大多数预测值都在两倍以内，估计的决定系数（R）>0.95。预测的肉牛肌肉 WDI 对于 PFOA 为<1 天，对于 PFOS 为 449 天，对于 PFHxS 为 69 天，而在高环境暴露情况下（例如，对于肉牛，PFOA、PFOS 和 PFHxS 的暴露量分别为 49.3、193 和 161ng/kg/天），奶牛的奶 WDI 预测值<1 天对于 PFOA，1345 天对于 PFOS，对于 PFHxS 则为零天。该模型被转换为基于网络的交互式通用 PBPK（igPBPK）平台，为预测牛中 PFAS 的组织和奶 WDI 提供了一个用户友好的仪表板。该模型为其他 PFAS 化合物的外推提供了基础，以改进牛源性食品产品的安全性评估。
