Ou Jiao Ying, Huang Di, Wu Yan Sheng, Xu Lin, He Fei, Wang Hui Ling, Shi Li Qiang, Wan Qiang, He Li Qun, Dong Gao Jian
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Department of Internal Medicine, Shanghai TCM-Integrated Hospital of Shanghai University of Traditional Chinese Medicine, No. 184 Baoding Road, Shanghai 200082, China.
Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, No. 528 Zhang Heng Road, Shanghai 201203, China.
Evid Based Complement Alternat Med. 2016;2016:3257603. doi: 10.1155/2016/3257603. Epub 2016 May 30.
Objective. The purpose of this systematic review is to evaluate the evidence of Yiqi Yangyin Huoxue Method for diabetic nephropathy. Methods. 11 electronic databases, through September 2015, were searched to identify randomized controlled trials of Yiqi Yangyin Huoxue Method for diabetic nephropathy. The quality of the included trials was assessed using the Jadad scale. Results. 26 randomized controlled trials were included in our review. Of all the included trials, most of them were considered as high quality. The aggregated results suggested that Yiqi Yangyin Huoxue Method is beneficial to diabetic nephropathy in bringing down the microalbuminuria (SMD = -0.98, 95% CI -1.22 to -0.74), serum creatinine (SMD = -0.56, 95% CI -0.93 to -0.20), beta-2 microglobulin (MD = 0.06, 95% CI 0.01 to 0.12), fasting plasma glucose (MD = -0.35, 95% CI -0.62 to -0.08), and 2-hour postprandial blood glucose (MD = 1.13, 95% CI 0.07 to 2.20), but not in decreasing blood urea nitrogen (SMD = -0.72, 95% CI -1.47 to 0.02) or 2-hour postprandial blood glucose (SMD = -0.48, 95% CI -1.01 to 0.04). Conclusions. Yiqi Yangyin Huoxue Method should be a valid complementary and alternative therapy in the management of diabetic nephropathy, especially in improving UAER, serum creatinine, fasting blood glucose, and beta-2 microglobulin. However, more studies with long follow-up are warrant to confirm the current findings.
目的。本系统评价旨在评估益气养阴活血法治疗糖尿病肾病的证据。方法。检索了截至2015年9月的11个电子数据库，以确定益气养阴活血法治疗糖尿病肾病的随机对照试验。采用Jadad量表评估纳入试验的质量。结果。我们的综述纳入了26项随机对照试验。在所有纳入的试验中，大多数被认为质量较高。汇总结果表明，益气养阴活血法有利于糖尿病肾病，可降低微量白蛋白尿（标准化均数差=-0.98，95%可信区间-1.22至-0.74）、血清肌酐（标准化均数差=-0.56，95%可信区间-0.93至-0.20）、β2微球蛋白（平均差=0.06，95%可信区间0.01至0.12）、空腹血糖（平均差=-0.35，95%可信区间-0.62至-0.08）和餐后2小时血糖（平均差=-1.13，95%可信区间0.07至2.20），但对降低血尿素氮（标准化均数差=-0.72，95%可信区间-1.47至0.02）或餐后2小时血糖（标准化均数差=-0.48，95%可信区间-1.01至0.04）无效。结论。益气养阴活血法应是糖尿病肾病管理中一种有效的补充和替代疗法，尤其是在改善尿白蛋白排泄率、血清肌酐、空腹血糖和β2微球蛋白方面。然而，需要更多长期随访的研究来证实目前的发现。
