Faculty of Medicine, Universidad Nacional Autónoma de México, Escolar 411A, 04360, Ciudad de Mexico, CDMX, Mexico.
Plan of Combined Studies in Medicine (PECEM, MD/PhD), Faculty of Medicine, Universidad Nacional Autónoma de México, Escolar 411A, 04360, Ciudad de Mexico, CDMX, Mexico.
J Neurooncol. 2023 Sep;164(3):535-543. doi: 10.1007/s11060-023-04448-7. Epub 2023 Sep 29.
This study aimed to identify if there are ethnic differences in the age and sex distribution of gliomas in the Latino adult population.
A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 recommendations. Databases used were MEDLINE, LILACS, Web of Science, and Scopus. Studies were included if they reported the age and/or sex distribution of gliomas in Latin adults, published in English or Spanish from January 1st, 1985, to December 1st, 2022. The quality of the studies was assessed using the Newcastle-Ottawa Quality Assessment Scale and the NIH Quality Assessment Tool.
From 1096 articles, fifteen studies with information on 6,815 patients were selected for the systematic review, and thirteen were selected for the meta-analysis. The mean ages of diagnosis of glioma and glioblastoma were 50.9, 95%\ CI [47.8-53.9] years and 53.33 years, 95 % CI [51-55.6], respectively. The male-to-female incidence rate ratio of gliomas was 1.39.
Our study found mean ages of glioma and glioblastoma were 6 and 10 years lower than those reported in the CBTRUS. Our study suggests disparities in the age and sex distribution of gliomas in Latin America compared to other regions.
CRD42021274423.
本研究旨在确定拉丁裔成年人中脑胶质瘤的年龄和性别分布是否存在种族差异。
根据系统评价和荟萃分析的首选报告项目（PRISMA）2020 建议进行系统评价和荟萃分析。使用的数据库是 MEDLINE、LILACS、Web of Science 和 Scopus。如果研究报告了拉丁裔成年人中脑胶质瘤的年龄和/或性别分布，并以英文或西语发表，且发表日期在 1985 年 1 月 1 日至 2022 年 12 月 1 日之间，则纳入研究。使用纽卡斯尔-渥太华质量评估量表和 NIH 质量评估工具评估研究质量。
从 1096 篇文章中，选择了 15 项研究进行系统评价，其中包含 6815 名患者的信息，选择了 13 项研究进行荟萃分析。脑胶质瘤和胶质母细胞瘤的平均诊断年龄分别为 50.9 岁，95%置信区间[47.8-53.9]岁和 53.33 岁，95%置信区间[51-55.6]岁。脑胶质瘤的男女发病比例为 1.39。
我们的研究发现，脑胶质瘤和胶质母细胞瘤的平均年龄比 CBTRUS 报告的年龄低 6 至 10 岁。我们的研究表明，拉丁美洲脑胶质瘤的年龄和性别分布与其他地区存在差异。
PROSPERO 注册号：CRD42021274423。
