Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.
The Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, NC.
Neuro Oncol. 2023 Feb 14;25(2):398-406. doi: 10.1093/neuonc/noac175.
Glioma incidence is 25% lower in Hispanics than White non-Hispanics. The US Hispanic population is diverse, and registry-based analyses may mask incidence differences associated with geographic/ancestral origins.
County-level glioma incidence data in Hispanics were retrieved from the Central Brain Tumor Registry of the United States. American Community Survey data were used to determine the county-level proportion of the Hispanic population of Mexican/Central American and Caribbean origins. Age-adjusted incidence rate ratios and incidence rate ratios (IRRs) quantified the glioma incidence differences across groups. State-level estimates of admixture in Hispanics were obtained from published 23andMe data.
Compared to predominantly Caribbean-origin counties, predominantly Mexican/Central American-origin counties had lower age-adjusted risks of glioma (IRR = 0.83; P < 0.0001), glioblastoma (IRR = 0.86; P < 0.0001), diffuse/anaplastic astrocytoma (IRR = 0.78; P < 0.0001), oligodendroglioma (IRR = 0.82; P < 0.0001), ependymoma (IRR = 0.88; P = 0.012), and pilocytic astrocytoma (IRR = 0.76; P < 0.0001). Associations were consistent in children and adults and using more granular geographic regions. Despite having lower glioma incidence, Hispanic glioblastoma patients from predominantly Mexican/Central American-origin counties had poorer survival than Hispanics living in predominantly Caribbean-origin counties. Incidence and survival differences could be partially explained by state-level estimates of European admixture in Hispanics with European admixture associated with higher incidence and improved survival.
Glioma incidence and outcomes differ in association with the geographic origins of Hispanic communities, with counties of predominantly Mexican/Central American origin at significantly reduced risk and those of Caribbean origin at comparatively greater risk. Although typically classified as a single ethnic group, appreciating the cultural, socioeconomic, and genetic diversity of Hispanics can advance cancer disparities research.
西班牙裔人群的脑胶质瘤发病率比非西班牙裔白人低 25%。美国的西班牙裔人口具有多样性，基于登记的分析可能掩盖了与地理/祖籍起源相关的发病率差异。
从美国中央脑肿瘤登记处获取西班牙裔人群的县级脑胶质瘤发病率数据。使用美国社区调查数据确定具有墨西哥/中美洲和加勒比起源的西班牙裔人群在县级的比例。年龄调整后的发病率比和发病率比（IRR）用于量化不同人群之间的脑胶质瘤发病率差异。从已发表的 23andMe 数据中获得西班牙裔人群混合程度的州级估计值。
与主要为加勒比起源的县相比，主要为墨西哥/中美洲起源的县脑胶质瘤的发病风险较低（IRR=0.83；P<0.0001），胶质母细胞瘤（IRR=0.86；P<0.0001）、弥漫性/间变性星形细胞瘤（IRR=0.78；P<0.0001）、少突胶质细胞瘤（IRR=0.82；P<0.0001）、室管膜瘤（IRR=0.88；P=0.012）和毛细胞星形细胞瘤（IRR=0.76；P<0.0001）。在儿童和成人中以及使用更细粒度的地理区域时，关联都是一致的。尽管脑胶质瘤发病率较低，但主要为墨西哥/中美洲起源的西班牙裔胶质母细胞瘤患者的生存情况不如主要为加勒比起源的县的西班牙裔患者。发病率和生存差异部分可以通过西班牙裔人群中欧洲混合程度的州级估计值来解释，具有欧洲混合程度的西班牙裔人群的发病率较高，生存情况得到改善。
与西班牙裔社区的地理起源相关，脑胶质瘤的发病率和结局存在差异，主要为墨西哥/中美洲起源的县发病率显著降低，而主要为加勒比起源的县发病率相对较高。尽管西班牙裔通常被归类为一个单一的族群，但了解西班牙裔人群的文化、社会经济和遗传多样性可以促进癌症差异研究。
