Department of Critical Care Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Immun Inflamm Dis. 2023 Sep;11(9):e1028. doi: 10.1002/iid3.1028.
Activating transcription factor 3 (ATF3) is a nuclear protein that is widely expressed in a variety of cells. It is a stress-inducible transcription gene and a member of the activating transcription factor/cAMP responsive element-binding protein (ATF/CREB) family.
The comprehensive literature review was conducted by searching PubMed and Google Scholar. Search terms used were "ATF3", "ATF3 and (ALI or ARDS)", "ATF3 and COPD", "ATF3 and PF", and "ATF3 and Posttranslational modifications".
Recent studies have shown that ATF3 plays a critical role in many inflammatory pulmonary diseases, including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis (PF). ATF3 participates in many signaling pathways and complex pathophysiological processes, such as inflammation, immunity, endoplasmic reticulum stress, and cell proliferation. However, the role of ATF3 in current studies is controversial, and there are reports showing that ATF3 plays different roles in different pulmonary diseases.
In this review, we first summarized the structure, function, and mechanism of ATF3 in various inflammatory pulmonary diseases. The impact of ATF3 on disease pathogenesis and the clinical implications was particularly focused on, with an overall aim to identify new targets for treating inflammatory pulmonary diseases.
激活转录因子 3（ATF3）是一种广泛表达于多种细胞中的核蛋白。它是一种应激诱导的转录基因，属于激活转录因子/环腺苷酸反应元件结合蛋白（ATF/CREB）家族成员。
通过检索 PubMed 和 Google Scholar 进行全面的文献回顾。使用的搜索词是“ATF3”、“ATF3 和（ALI 或 ARDS）”、“ATF3 和 COPD”、“ATF3 和 PF”以及“ATF3 和翻译后修饰”。
最近的研究表明，ATF3 在许多炎症性肺疾病中起着关键作用，包括急性肺损伤（ALI）/急性呼吸窘迫综合征（ARDS）、慢性阻塞性肺疾病（COPD）和肺纤维化（PF）。ATF3 参与许多信号通路和复杂的病理生理过程，如炎症、免疫、内质网应激和细胞增殖。然而，目前研究中 ATF3 的作用存在争议，有报道称 ATF3 在不同的肺部疾病中发挥不同的作用。
在这篇综述中，我们首先总结了 ATF3 在各种炎症性肺疾病中的结构、功能和机制。特别关注了 ATF3 对疾病发病机制的影响及其临床意义，旨在确定治疗炎症性肺疾病的新靶点。
