Tang Zhigang, Pu Ning, Zhong Zheren, Lu Rong, Wei Xiaochen, Wu Pan
Department of Rehabilitation Acupuncture and Moxibustion, The First People's Hospital of Lanzhou City No. 1 Wujiayuan West Street, Qilihe District, Lanzhou 730050, Gansu, China.
Department of Environmental Protection, The First People's Hospital of Lanzhou City No. 1 Wujiayuan West Street, Qilihe District, Lanzhou 730050, Gansu, China.
Am J Transl Res. 2024 Nov 15;16(11):6435-6446. doi: 10.62347/CQIR3328. eCollection 2024.
To evaluate the response and safety of combining acupuncture based on the Dunhuang "Moxibustion Classic" with carbamazepine in the treatment of neuropathic tinnitus.
A retrospective analysis was conducted on 105 patients with neuropathic tinnitus treated at The First People's Hospital of Lanzhou City from January 2019 to February 2023. Of these, 49 patients received acupuncture based on the Dunhuang "Moxibustion Classic" (research group), while 56 patients received conventional acupuncture (control group). Both groups were treated with carbamazepine in combination. The Tinnitus Handicap Inventory (THI), Tinnitus Evaluation Questionnaire (TEQ), Visual Analogue Scale for Aural Fullness (VAS), Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD) scores were compared between the two groups. Treatment response and Pittsburgh Sleep Quality Index (PSQI) scores were also analyzed. Logistic regression analysis was performed to identify risk factors affecting patients' sleep quality.
The overall response rate in the control group was significantly lower than that in the research group (P = 0.037). After treatment, THI, PSQI, TEQ, VAS, HAMA, and HAMD scores were higher in the control group than in the research group (P<0.05). The incidence of adverse reactions was significantly higher in the control group than in the research group (P = 0.025). Multivariate logistic regression analysis identified treatment options (P = 0.002, OR = 8.612, 95% CI = 2.466-39.565), disease duration (P = 0.687, OR = 0.779, 95% CI = 0.219-2.544), pre-treatment THI (P = 0.002, OR = 7.061, 95% CI = 2.17-26.368), pre-treatment TEQ (P<0.001, OR = 14.654, 95% CI = 4.196-65.376), and pre-treatment HAMA (P = 0.019, OR = 3.805, 95% CI = 1.271-12.209) as independent risk factors for impaired sleep quality.
The combination of Dunhuang "Moxibustion Classic" acupuncture with carbamazepine is an effective and safe treatment for neuropathic tinnitus, leading to greater improvements in symptoms, sleep quality, anxiety, and depression compared to conventional acupuncture.
评估基于敦煌《灸经》的针灸联合卡马西平治疗神经性耳鸣的疗效及安全性。
对2019年1月至2023年2月在兰州市第一人民医院治疗的105例神经性耳鸣患者进行回顾性分析。其中，49例患者接受基于敦煌《灸经》的针灸治疗（研究组），56例患者接受传统针灸治疗（对照组）。两组均联合卡马西平治疗。比较两组的耳鸣 handicap 量表（THI）、耳鸣评估问卷（TEQ）、耳胀满视觉模拟量表（VAS）、汉密尔顿焦虑量表（HAMA）和汉密尔顿抑郁量表（HAMD）评分。分析治疗反应及匹兹堡睡眠质量指数（PSQI）评分。进行逻辑回归分析以确定影响患者睡眠质量的危险因素。
对照组的总有效率显著低于研究组（P = 0.037）。治疗后，对照组的THI、PSQI、TEQ、VAS、HAMA和HAMD评分高于研究组（P<0.05）。对照组的不良反应发生率显著高于研究组（P = 0.025）。多因素逻辑回归分析确定治疗方式（P = 0.002，OR = 8.612，95%CI = 2.466 - 39.565）、病程（P = 0.687，OR = 0.779，95%CI = 0.219 - 2.544）、治疗前THI（P = 0.002，OR = 7.061，95%CI = 2.17 - 26.368）、治疗前TEQ（P<0.001，OR = 14.654，95%CI = 4.196 - 65.376）和治疗前HAMA（P = 0.019，OR = 3.805，95%CI = 1.271 - 12.209）为睡眠质量受损的独立危险因素。
敦煌《灸经》针灸联合卡马西平是治疗神经性耳鸣的一种有效且安全的方法，与传统针灸相比，在症状、睡眠质量、焦虑和抑郁方面有更大改善。
