Department of Diagnosis and Surgery, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil.
Department of Dental Prothesis, São Paulo State University (UNESP), School of Dentistry, Araraquara, São Paulo, Brazil.
Asian Pac J Cancer Prev. 2023 Sep 1;24(9):2929-2940. doi: 10.31557/APJCP.2023.24.9.2929.
The present study performed a systematic review and meta-analysis of observational studies on whether calreticulin levels could represent a prognostic factor in carcinoma patients. Calreticulin (CRT) is a multifunctional protein in the endoplasmic reticulum that can play distinct roles in different cancers.
The search was performed in PubMed, Scopus, the Cochrane Library, Web of Science, Lilacs, Science Direct, Embase, Bireme, and SciELO databases. After a full-text evaluation, only 14 articles remained. The RoBANS tool assessed the risk of bias. The meta-analysis was performed with R software, and the odds ratio (OR) was the effect measure. The random effects model was chosen, and the quality of evidence was evaluated according to GRADE.
The most frequent carcinomas were in the breasts and the colon. CRT expression varied according to carcinoma origin and type, but these diseases had a prevalence of high CRT levels, indicating tumor progression. The high CRT levels were associated with lymph node metastasis (OR = 3.06 [1.71; 5.48]/p = 0.0002/I2 = 0%). All included articles had a blinding bias.
High CRT levels may represent a prognostic factor for metastatic lymph nodes in carcinoma patients.
本研究对观察性研究进行了系统评价和荟萃分析，以评估钙网织蛋白（CRT）水平是否可以作为癌患者的预后因素。钙网织蛋白（CRT）是内质网中的一种多功能蛋白，在不同的癌症中可以发挥不同的作用。
在 PubMed、Scopus、Cochrane 图书馆、Web of Science、Lilacs、Science Direct、Embase、Bireme 和 SciELO 数据库中进行了检索。经过全文评估，仅保留了 14 篇文章。使用 RoBANS 工具评估偏倚风险。使用 R 软件进行荟萃分析，效应量为比值比（OR）。选择随机效应模型，并根据 GRADE 评估证据质量。
最常见的癌发生在乳房和结肠。CRT 表达因癌起源和类型而异，但这些疾病普遍存在 CRT 水平升高，表明肿瘤进展。高 CRT 水平与淋巴结转移相关（OR = 3.06 [1.71; 5.48]/p = 0.0002/I2 = 0%）。所有纳入的文章都存在盲法偏倚。
高 CRT 水平可能是癌患者发生转移性淋巴结的预后因素。
