Xia Lu, Mei Jie, Huang Min, Bao Dandan, Wang Zhiwei, Chen Yizhe
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.
Transl Oncol. 2025 Jan;51:102220. doi: 10.1016/j.tranon.2024.102220. Epub 2024 Nov 30.
Ovarian cancer is a prevalent malignancy among women, often associated with a poor prognosis. Post-translational modifications (PTMs), particularly O-GlcNAcylation, have been implicated in the progression of ovarian cancer. Emerging evidence indicates that dysregulation of O-GlcNAcylation contributes to the initiation and malignant progression of ovarian cancer. This review discusses the potential role of O-GlcNAcylation in ovarian tumorigenesis, with a focus on its regulation of various cellular signaling pathways, including p53, RhoA/ROCK/MLC, Ezrin/Radixin/Moesin (ERM), and β-catenin. This review also emphasizes the O-GlcNAcylation of critical proteins in ovarian cancer, such as SNAP-23, SNAP-29, E-cadherin, and calreticulin. Additionally, the potential of O-GlcNAcylation to enhance immunotherapy for ovarian cancer patients is explored. Several compounds targeting OGT and OGA in ovarian cancer are also highlighted. Targeting the dynamic and versatile nature of O-GlcNAcylation could undoubtedly contribute to more effective treatments and improved outcomes for ovarian cancer patients.
卵巢癌是女性中常见的恶性肿瘤，通常预后较差。翻译后修饰（PTM），尤其是O-连接的N-乙酰葡糖胺化（O-GlcNAcylation），与卵巢癌的进展有关。新出现的证据表明，O-GlcNAcylation的失调促成了卵巢癌的发生和恶性进展。本综述讨论了O-GlcNAcylation在卵巢肿瘤发生中的潜在作用，重点关注其对各种细胞信号通路的调节，包括p53、RhoA/ROCK/MLC、埃兹蛋白/根蛋白/膜突蛋白（ERM）和β-连环蛋白。本综述还强调了卵巢癌中关键蛋白的O-GlcNAcylation，如SNAP-23、SNAP-29、E-钙黏蛋白和钙网蛋白。此外，还探讨了O-GlcNAcylation增强卵巢癌患者免疫治疗的潜力。还重点介绍了几种针对卵巢癌中OGT和OGA的化合物。针对O-GlcNAcylation的动态和多功能特性无疑有助于为卵巢癌患者提供更有效的治疗并改善预后。
