O'Brodovich H, Coates G
Am Rev Respir Dis. 1986 Nov;134(5):862-6. doi: 10.1164/arrd.1986.134.5.862.
To investigate the effect of increased cardiac output on lung water and solute movement in abnormally permeable lungs, experiments were performed in sheep with chronic vascular catheters and lung lymph fistulas. Pulmonary permeability was increased by infusing air microemboli intravenously for 3 h. Once stable lymph flow was observed after stopping the air embolization sheep were either exercised on a treadmill to increase cardiac output (n = 10) or merely continuously monitored (control experiments, n = 6). In control experiments, lung lymph flow remained at markedly elevated but stable values. Sheep exercised for a median time of 45 min. Cardiac output increased 85%, whereas lung lymph flow, in terms of baseline flow rates, increased 296%. The lymph to plasma concentration ratio for total protein was unchanged, and left atrial pressure remained stable and normal during exercise. During exercise, pulmonary arterial pressure increased by 3 mm Hg. The data, when compared with previous observations in normal sheep, demonstrate that exercise-induced increases in cardiac output result in disproportionate increases in lung lymph flow when pulmonary vascular permeability is increased.
为研究心输出量增加对通透性异常肺组织中肺水及溶质转运的影响，我们对植入慢性血管导管及肺淋巴瘘管的绵羊进行了实验。通过静脉输注空气微栓3小时来增加肺通透性。停止空气栓塞后，一旦观察到淋巴液流量稳定，将绵羊置于跑步机上运动以增加心输出量（n = 10），或仅进行持续监测（对照实验，n = 6）。在对照实验中，肺淋巴液流量维持在显著升高但稳定的水平。运动的绵羊中位运动时间为45分钟。心输出量增加了85%，而以基础流量计算，肺淋巴液流量增加了296%。运动期间，总蛋白的淋巴液与血浆浓度比值未变，左心房压力保持稳定且正常。运动期间，肺动脉压升高了3 mmHg。与先前对正常绵羊的观察结果相比，这些数据表明，当肺血管通透性增加时，运动诱导的心输出量增加会导致肺淋巴液流量不成比例地增加。
