Li Ketao, Chen Wan, Ma Liping, Yan Laixing, Wang Bing
Department of Cardiology, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, Zhejiang, 310022, China.
Department of Cardiology, Jiulongpo First People's Hospital, Chongqing, 400051, China.
Environ Res. 2024 Mar 1;244:117264. doi: 10.1016/j.envres.2023.117264. Epub 2023 Sep 28.
Nanoparticles are fascinating and encouraging carriers for cancer treatment due to their extraordinary properties and potential applications in targeted drug delivery, treatment, and diagnosis. Experimental studies including in vitro and in vivo examinations show that nanoparticles can cause a revolution in different aspects of cancer therapy. Normal tissue toxicity and early and late consequences are the major limitations of cancer therapy by radiotherapy and chemotherapy. However, the delivery of drugs into tumors or reducing the accumulation of drugs in normal tissues can permit a more satisfactory response of malignancies to therapy with more inferior side effects. Cardiac toxicity is one of the major problems for chemotherapy and radiotherapy. Therefore, several experimental studies have been performed to minimize the degenerative impacts of cancer treatment on the heart and also enhance the influences of radiotherapy and chemotherapy agents in cancers. This review article emphasizes the benefits of nanoparticle-based drug delivery techniques, including minimizing the exposure of the heart to anticancer drugs, enhancing the accumulation of drugs in cancers, and expanding the effectiveness of radiotherapy. The article also discusses the challenges and problems accompanied with nanoparticle-based drug delivery techniques such as toxicity, which need to be addressed through further research. Moreover, the article emphasizes the importance of developing safe and effective nanoparticle-based therapies that can be translated into clinical practice.
由于其非凡的特性以及在靶向给药、治疗和诊断方面的潜在应用，纳米颗粒是用于癌症治疗的极具吸引力且令人鼓舞的载体。包括体外和体内检查在内的实验研究表明，纳米颗粒可在癌症治疗的不同方面引发一场革命。正常组织毒性以及早期和晚期后果是放疗和化疗治疗癌症的主要局限性。然而，将药物递送至肿瘤或减少药物在正常组织中的蓄积，可以使恶性肿瘤对治疗产生更令人满意的反应，同时副作用更小。心脏毒性是化疗和放疗的主要问题之一。因此，已经进行了多项实验研究，以尽量减少癌症治疗对心脏的退行性影响，并增强放疗和化疗药物对癌症的作用。这篇综述文章强调了基于纳米颗粒的给药技术的益处，包括减少心脏对抗癌药物的暴露、增强药物在癌症中的蓄积以及扩大放疗的效果。文章还讨论了基于纳米颗粒的给药技术所伴随的挑战和问题，如毒性，这些问题需要通过进一步研究来解决。此外，文章强调了开发能够转化为临床实践的安全有效的基于纳米颗粒的疗法的重要性。
