Liu Yihong, Liu Jingwei, Peng Na, Hai Shuangshuang, Zhang Shen, Zhao Haibo, Liu Weixin
Department of Gastroenterology, the First Affiliated Hospital of China Medical University, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China.
Department of Anus and Intestine Surgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
Cancer Cell Int. 2023 Sep 30;23(1):225. doi: 10.1186/s12935-023-03062-x.
Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosphorylation are closely implicated in different aspects of gastrointestinal tumors. Recently, emerging evidence showed that non-canonical PTMs play an essential role in the carcinogenesis, metastasis and treatment of gastrointestinal tumors. Therefore, we summarized recent advances in sumoylation, neddylation, isoprenylation, succinylation and other non-canonical PTMs in gastrointestinal tumors, which comprehensively describe the mechanisms and functions of non-classical PTMs in gastrointestinal tumors. It is anticipated that targeting specific PTMs could benefit the treatment as well as improve the prognosis of gastrointestinal tumors.
蛋白质的翻译后修饰（PTMs）有助于肿瘤的发生和发展。先前的研究表明，泛素化、糖基化和磷酸化等经典PTMs与胃肠道肿瘤的不同方面密切相关。最近，新出现的证据表明，非经典PTMs在胃肠道肿瘤的致癌作用、转移和治疗中发挥着重要作用。因此，我们总结了近期在胃肠道肿瘤中SUMO化、NEDD化、异戊二烯化、琥珀酰化及其他非经典PTMs方面的进展，全面描述了非经典PTMs在胃肠道肿瘤中的机制和功能。预计靶向特定的PTMs可能有利于胃肠道肿瘤的治疗并改善其预后。
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