Department of Neurology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, 155 Hanzhong Road, Nanjing, 210029, China.
Friend Plastic Hospital of Nanjing Medical University, Nanjing, 210029, China.
J Neuroinflammation. 2023 Sep 30;20(1):220. doi: 10.1186/s12974-023-02890-y.
To explore the association of systemic inflammatory index (SIRI), systemic immune-inflammatory index (SII) and inflammatory prognosis index (IPI) with 90d outcomes in patients with acute ischemic stroke (AIS) after intravenous thrombolysis.
The patients who underwent intravenous thrombolysis were enrolled in the present study from September 2019 to December 2022. According to the relevant blood indexes obtained in 24 h after admission, the corresponding values of SIRI, SII and IPI were calculated. The correlation among SIRI, SII, IPI, and admission NIHSS scores was examined by Spearman correlation analysis. ROC curve analysis was conducted to determine the optimal cut-off value of SIRI, SII, IPI, and their corresponding sensitivity and specificity to evaluate their predictive value on admission for poor prognosis. To investigate whether high SIRI, SII, and IPI were independent predictors of poor outcomes within 90 days, variables with P-value < 0.05 during univariate analysis were included in multivariate analysis.
Compared with the good outcome group, the poor outcome group had higher SIRI, IPI, and SII. Spearman correlation analysis showed that the SIRI, IPI, and SII levels significantly correlated with the admission NIHSS score (r = 0.338, 0.356, 0.427, respectively; P < 0.001). Univariate analysis and Multivariate logistic regression analysis revealed high SIRI, SII, and IPI values as independent risk factors for poor 90-day prognosis (OR = 1.09, 1.003 and 7.109, respectively).
High SIRI, IPI, and SII values are correlated with poor 90d outcomes in AIS patients undergoing intravenous thrombolysis.
探讨全身炎症指数（SIRI）、全身免疫炎症指数（SII）和炎症预后指数（IPI）与急性缺血性脑卒中（AIS）患者静脉溶栓后 90d 结局的关系。
本研究纳入 2019 年 9 月至 2022 年 12 月期间行静脉溶栓的患者。根据入院 24h 内获得的相关血液指标，计算相应的 SIRI、SII 和 IPI 值。采用 Spearman 相关分析检验 SIRI、SII、IPI 与入院 NIHSS 评分之间的相关性。通过 ROC 曲线分析确定 SIRI、SII、IPI 及其相应的最佳截断值，评估其对入院时预后不良的预测价值。为探讨 SIRI、SII 和 IPI 升高是否为 90d 内不良结局的独立预测因素，将单因素分析中 P 值<0.05 的变量纳入多因素分析。
与预后良好组相比，预后不良组的 SIRI、IPI 和 SII 较高。Spearman 相关分析显示，SIRI、IPI 和 SII 水平与入院 NIHSS 评分显著相关（r=0.338、0.356 和 0.427，P<0.001）。单因素分析和多因素 logistic 回归分析显示，高 SIRI、SII 和 IPI 值是 90d 预后不良的独立危险因素（OR=1.09、1.003 和 7.109）。
SIRI、IPI 和 SII 值与 AIS 患者静脉溶栓后 90d 预后不良相关。
