Brolin J, Lahnborg G, Ljung A, Rietz K A
Ann Chir Gynaecol. 1986;75(4):219-24.
The aim of this study was to compare the prophylactic effects of netilmicin plus metronidazole administered for one day and of doxycycline administered for five days on the incidence of postoperative sepsis in patients undergoing elective colorectal surgery. One hundred patients were studied, 50 men and 50 women, with a mean age of 66.6 years. The patients were randomized into the two groups. Wound infections occurred in a total of 9 patients, 5 in the doxycycline group and 4 in the group given netilmicin plus metronidazole, i.e. the overall infection rate was 9%. It is concluded that there is no statistically significant difference on the incidence of postoperative wound sepsis in patients undergoing elective colorectal surgery between the group given doxycycline for five days and the group given netilmicin plus metronidazole for one day.
本研究的目的是比较奈替米星加甲硝唑一日给药方案与多西环素五日给药方案对择期结直肠手术患者术后脓毒症发生率的预防效果。研究对象为100例患者，男女各50例，平均年龄66.6岁。患者被随机分为两组。共有9例患者发生伤口感染，多西环素组5例，奈替米星加甲硝唑组4例，即总体感染率为9%。得出的结论是，对于择期结直肠手术患者，五日给药的多西环素组与一日给药的奈替米星加甲硝唑组在术后伤口脓毒症发生率上无统计学显著差异。
