Viddal K O, Semb L S
Scand J Gastroenterol Suppl. 1980;59:21-4.
Forty-two patients admitted for elective colorectal surgery were given tinidazole and doxycycline or doxycycline alone as prophylactic antimicrobials in a double-blind study. There was altogether one abdominal wound infection (2.4%), and one patient developed a perineal fistula three months after the operation. No significant difference in postoperative infections between the two groups could be demonstrated. It is concluded that doxycycline seems effective in reducing wound sepsis after operations on the large intestine and that additional administration of tinidazole will yield little in prophylaxis.
在一项双盲研究中，42名因择期结直肠手术入院的患者被给予替硝唑和多西环素或仅给予多西环素作为预防性抗菌药物。总共发生1例腹部伤口感染（2.4%），1例患者术后3个月出现会阴瘘。两组之间术后感染无显著差异。得出的结论是，多西环素似乎对减少大肠手术后的伤口脓毒症有效，额外给予替硝唑在预防方面收效甚微。
