Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Mass; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Mass.
Division of Immunology, Boston Children's Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass.
J Allergy Clin Immunol. 2024 Jan;153(1):28-41. doi: 10.1016/j.jaci.2023.09.025. Epub 2023 Sep 29.
Regulatory T cells expressing the transcription factor forkhead box protein 3 mediate peripheral immune tolerance both to self-antigens and to the commensal flora. Their defective function due to inborn errors of immunity or acquired insults is associated with a broad range of autoimmune and immune dysregulatory diseases. Although their function in suppressing autoimmunity and enforcing commensalism is established, a broader role for regulatory T cells in tissue repair and metabolic regulation has emerged, enabled by unique programs of tissue adaptability and specialization. In this review, we focus on the myriad roles played by regulatory T cells in immunologic tolerance and host homeostasis and the potential to harness these cells in novel therapeutic approaches to human diseases.
表达转录因子叉头框蛋白 3 的调节性 T 细胞介导外周免疫耐受，既针对自身抗原，也针对共生菌群。由于先天免疫缺陷或后天损伤，其功能缺陷与广泛的自身免疫和免疫失调性疾病相关。尽管调节性 T 细胞在抑制自身免疫和执行共生方面的功能已得到确立，但它们在组织修复和代谢调节中的更广泛作用也已显现，这得益于组织适应性和专业化的独特程序。在这篇综述中，我们重点介绍调节性 T 细胞在免疫耐受和宿主内稳态中发挥的多种作用，以及利用这些细胞开发新型治疗人类疾病的潜在方法。
