School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Jiangsu, Nanjing, 210023, China.
School of Bioengineering, East China University of Science and Technology, Shanghai, 200237, China.
Environ Res. 2023 Dec 15;239(Pt 1):117211. doi: 10.1016/j.envres.2023.117211. Epub 2023 Sep 29.
The development of the chemical industry has led to a boom in daily consumption and convenience, but has also led to the release of large amounts of organic pollutants, such as petroleum hydrocarbons, plastics, pesticides, and dyes. These pollutants are often recalcitrant to degradation in the environment, whereby the most problematic compounds may even lead to carcinogenesis, teratogenesis and mutagenesis in animals and humans after accumulation in the food chain. Microbial degradation of organic pollutants is efficient and environmentally friendly, which is why it is considered an ideal method. Numerous studies have shown that Pseudomonas aeruginosa is a powerful platform for the remediation of environmental pollution with organic chemicals due to its diverse metabolic networks and its ability to secrete biosurfactants to make hydrophobic substrates more bioavailable, thereby facilitating degradation. In this paper, the mechanisms and methods of the bioremediation of environmental organic pollutants (EOPs) by P. aeruginosa are reviewed. The challenges of current studies are highlighted, and new strategies for future research are prospected. Metabolic pathways and critical enzymes must be further deciphered, which is significant for the construction of a bioremediation platform based on this powerful organism.
化学工业的发展带来了日常消费和便利的繁荣，但也导致了大量有机污染物的释放，如石油烃、塑料、农药和染料。这些污染物在环境中往往难以降解，其中最具问题的化合物在食物链中积累后，甚至可能导致动物和人类致癌、致畸和致突变。微生物降解有机污染物高效且环保，因此被认为是一种理想的方法。大量研究表明，由于其多样化的代谢网络及其分泌生物表面活性剂的能力，使疏水性底物更具生物利用度，从而促进降解，铜绿假单胞菌是一种用于修复有机化学环境污染的强大平台。本文综述了铜绿假单胞菌对环境有机污染物（EOPs）的生物修复机制和方法。强调了当前研究的挑战，并展望了未来研究的新策略。必须进一步破译代谢途径和关键酶，这对于构建基于这种强大生物体的生物修复平台具有重要意义。
