Department of Pulmonary Medicine, Gifu Prefectural General Medical Center, Japan.
Department of Pathology, Gifu Prefectural General Medical Center, Japan.
Intern Med. 2023 Dec 1;62(23):3519-3523. doi: 10.2169/internalmedicine.2006-23. Epub 2023 Sep 29.
The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Autopsy findings included hyaline membrane formation/interstitial inflammatory cell infiltration, suggestive of acute lesions, and severe regional fibrosis, indicating a preexisting chronic condition. In the present case, we histopathologically confirmed the acute exacerbation of post-COVID-19 interstitial lung disease.
新型冠状病毒病(COVID-19)后间质性肺病患者的预后仍不清楚。本文报告了一例 COVID-19 后间质性肺病发病后连续进展导致急性加重,最终导致死亡的尸检病例。尸检发现包括透明膜形成/间质炎症细胞浸润,提示急性病变,以及严重的区域性纤维化,表明存在先前存在的慢性疾病。在本病例中,我们从组织病理学上证实了 COVID-19 后间质性肺病的急性加重。