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COVID-19 后间质性肺病伴急性加重的尸检病例。

An Autopsy Case of Post-COVID-19 Interstitial Lung Disease with Acute Exacerbation.

机构信息

Department of Pulmonary Medicine, Gifu Prefectural General Medical Center, Japan.

Department of Pathology, Gifu Prefectural General Medical Center, Japan.

出版信息

Intern Med. 2023 Dec 1;62(23):3519-3523. doi: 10.2169/internalmedicine.2006-23. Epub 2023 Sep 29.

DOI:10.2169/internalmedicine.2006-23
PMID:37779072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10749816/
Abstract

The prognosis of patients with post-coronavirus disease 2019 (COVID-19) interstitial lung disease remains unclear. We herein report an autopsy case in which serial progression after the onset of post-COVID-19 interstitial lung disease resulted in an acute exacerbation, leading to a fatal outcome. Autopsy findings included hyaline membrane formation/interstitial inflammatory cell infiltration, suggestive of acute lesions, and severe regional fibrosis, indicating a preexisting chronic condition. In the present case, we histopathologically confirmed the acute exacerbation of post-COVID-19 interstitial lung disease.

摘要

新型冠状病毒病（COVID-19）后间质性肺病患者的预后仍不清楚。本文报告了一例 COVID-19 后间质性肺病发病后连续进展导致急性加重，最终导致死亡的尸检病例。尸检发现包括透明膜形成/间质炎症细胞浸润，提示急性病变，以及严重的区域性纤维化，表明存在先前存在的慢性疾病。在本病例中，我们从组织病理学上证实了 COVID-19 后间质性肺病的急性加重。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/10749816/18ad192e4348/1349-7235-62-3519-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/10749816/1f3edcbffb07/1349-7235-62-3519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/10749816/640853ffcd47/1349-7235-62-3519-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/10749816/18ad192e4348/1349-7235-62-3519-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/10749816/1f3edcbffb07/1349-7235-62-3519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/10749816/640853ffcd47/1349-7235-62-3519-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d02/10749816/18ad192e4348/1349-7235-62-3519-g003.jpg

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