链霉菌属的抗真菌大环二醇物
Antifungal macrodiolide from Streptomyces sp.
作者信息
Jois H R, Sarkar A, Gurusiddaiah S
出版信息
Antimicrob Agents Chemother. 1986 Sep;30(3):458-64. doi: 10.1128/AAC.30.3.458.
Abstract
Aerobic fermentation cultures of Streptomyces sp. produced an antifungal macrodiolide. This new antibiotic consists of two units of homononactic acid linked to form a cyclic diester. An unknown polypeptide was also isolated in trace quantities. The antibiotic with polypeptide complex showed high levels of antifungal activity compared with that of the macrodiolide alone. The macrodiolide also showed a stimulatory effect on some species of fungi. The production, purification, and characterization of these compounds are reported.
摘要
链霉菌属的需氧发酵培养物产生了一种抗真菌大环二萜内酯。这种新抗生素由两个高诺那酸单元连接形成一个环状二酯。还微量分离出一种未知的多肽。与单独的大环二萜内酯相比，含有多肽复合物的抗生素表现出高水平的抗真菌活性。大环二萜内酯对某些真菌种类也有刺激作用。本文报道了这些化合物的生产、纯化和表征。
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