Netland A, Müller C, Andrew E
Scand J Infect Dis. 1981;13(4):273-5. doi: 10.3109/inf.1981.13.issue-4.06.
10 adults with bacterial meningitis were given 1.5 g cefuroxime intravenously 4 time daily in addition to the normal antibiotic treatment. CSF levels of cefuroxime ranged from 1.5 to 13.5 mg/l (mean 6.0 mg/l) in the aucte stage of the disease. In the convalescent stage, the cefuroxime levels in the CSF varied from less than 1 to 7.5 mg/l (mean 3.2 mg/l). The CSF levels of cefuroxime in all but one measurement, by far exceeded the MIC values reported for the vast majority of strains of the pathogen commonly associated with meningitis.
10名患有细菌性脑膜炎的成年人在接受常规抗生素治疗的基础上，每天静脉注射4次1.5克头孢呋辛。在疾病急性期，脑脊液中头孢呋辛的水平在1.5至13.5毫克/升之间（平均6.0毫克/升）。在恢复期，脑脊液中头孢呋辛的水平在低于1至7.5毫克/升之间（平均3.2毫克/升）。除一次测量外，头孢呋辛在脑脊液中的水平远远超过了报道的绝大多数与脑膜炎常见相关病原体菌株的最低抑菌浓度值。
