School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China.
Department of Bioinformatics, Fujian Key Laboratory of Medical Bioinformatics, School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, China.
Brief Bioinform. 2023 Sep 22;24(6). doi: 10.1093/bib/bbad340.
The microbiota-gut-brain axis denotes a two-way system of interactions between the gut and the brain, comprising three key components: (1) gut microbiota, (2) intermediates and (3) mental ailments. These constituents communicate with one another to induce changes in the host's mood, cognition and demeanor. Knowledge concerning the regulation of the host central nervous system by gut microbiota is fragmented and mostly confined to disorganized or semi-structured unrestricted texts. Such a format hinders the exploration and comprehension of unknown territories or the further advancement of artificial intelligence systems. Hence, we collated crucial information by scrutinizing an extensive body of literature, amalgamated the extant knowledge of the microbiota-gut-brain axis and depicted it in the form of a knowledge graph named MMiKG, which can be visualized on the GraphXR platform and the Neo4j database, correspondingly. By merging various associated resources and deducing prospective connections between gut microbiota and the central nervous system through MMiKG, users can acquire a more comprehensive perception of the pathogenesis of mental disorders and generate novel insights for advancing therapeutic measures. As a free and open-source platform, MMiKG can be accessed at http://yangbiolab.cn:8501/ with no login requirement.
肠脑轴表示肠道和大脑之间的双向相互作用系统，由三个关键组成部分组成：（1）肠道微生物群，（2）中间产物和（3）精神疾病。这些成分相互交流，引起宿主情绪、认知和行为的变化。关于肠道微生物群对宿主中枢神经系统的调节的知识是零散的，并且主要局限于无组织或半结构化的不受限制的文本。这种格式阻碍了对未知领域的探索和理解，或人工智能系统的进一步发展。因此，我们通过仔细审查大量文献来整理关键信息，将现有的肠脑轴知识合并，并以名为 MMiKG 的知识图的形式呈现出来，该知识图可以在 GraphXR 平台和 Neo4j 数据库上可视化。通过将各种相关资源合并，并通过 MMiKG 推断肠道微生物群与中枢神经系统之间的潜在联系，用户可以更全面地了解精神障碍的发病机制，并为推进治疗措施提供新的见解。作为一个免费和开源的平台，MMiKG 可以在无需登录的情况下访问 http://yangbiolab.cn:8501/。
