Clinical Medical College of China Medical University, Shen Yang 110000, China.
Department of Histology and Embryology, Basic Medical College, China Medical University, Shen Yang 110000, China.
Curr Pharm Des. 2023;29(28):2213-2222. doi: 10.2174/0113816128257113230921035222.
The literature review reveals that NEAT1 is dysregulated in gastric cancer and plays a critical role in various aspects of tumorigenesis, including cell proliferation, invasion, metastasis, and chemotherapy resistance. NEAT1 exerts its functions through interactions with proteins, DNA, and other RNAs, acting as a scaffold or by modulating chromatin modifications and gene expression. Furthermore, NEAT1 is involved in epithelial-mesenchymal transition (EMT), angiogenesis, and immune evasion, contributing to the aggressive behavior of gastric cancer cells. The dysregulation of NEAT1 has been reported to be associated with clinicopathological features, prognosis, and therapeutic response in gastric cancer patients.
A systematic literature search was performed on PubMed from September 2016 to the present using the keywords "LncRNA NEAT1" and "gastric cancer". A total of 32 articles were identified. Studies investigating the regulatory mechanisms of NEAT1 in other tumors were excluded from this review. Additionally, to provide a more comprehensive understanding of the molecular mechanisms underlying NEAT1-mediated gastric cancer development, 27 additional articles were included.
LncRNA NEAT1 plays a pivotal role in gastric cancer, exerting significant effects on proliferation, invasion, metastasis, autophagy, apoptosis, drug resistance, and overall survival. The underlying molecular mechanisms involve miRNA sequestration, protein-protein interactions, transcriptional regulation, DNA methylation modifications, and activation of canonical signaling pathways. These findings underscore the multifaceted involvement of lncRNA NEAT1 in the pathogenesis and therapeutic resistance of gastric cancer, providing valuable insights into potential therapeutic targets and prognostic biomarkers.
LncRNA NEAT1 is intricately involved in the pathogenesis of gastric cancer through various molecular mechanisms. Additionally, lncRNA NEAT1 is closely associated with radiotherapy resistance and adverse prognosis in gastric cancer patients, indicating its potential as a promising independent risk factor for clinical treatment targeting and prognostic prediction.
文献综述表明，NEAT1 在胃癌中失调，在肿瘤发生的各个方面发挥关键作用，包括细胞增殖、侵袭、转移和化疗耐药性。NEAT1 通过与蛋白质、DNA 和其他 RNA 相互作用发挥其功能，充当支架或通过调节染色质修饰和基因表达。此外，NEAT1 参与上皮-间充质转化（EMT）、血管生成和免疫逃逸，促进胃癌细胞的侵袭性行为。NEAT1 的失调已被报道与胃癌患者的临床病理特征、预后和治疗反应有关。
使用关键词“LncRNA NEAT1”和“gastric cancer”，对 2016 年 9 月至目前为止的 PubMed 进行了系统的文献检索。共确定了 32 篇文章。本综述排除了研究 NEAT1 在其他肿瘤中调节机制的文章。此外，为了更全面地了解 NEAT1 介导的胃癌发生的分子机制，还纳入了 27 篇额外的文章。
LncRNA NEAT1 在胃癌中发挥重要作用，对增殖、侵袭、转移、自噬、凋亡、耐药性和总生存有显著影响。潜在的分子机制包括 miRNA 结合、蛋白-蛋白相互作用、转录调控、DNA 甲基化修饰和经典信号通路的激活。这些发现强调了长链非编码 RNA NEAT1 在胃癌发病机制和治疗耐药性中的多方面作用，为潜在的治疗靶点和预后生物标志物提供了有价值的见解。
LncRNA NEAT1 通过多种分子机制参与胃癌的发病机制。此外，LncRNA NEAT1 与胃癌患者的放疗耐药性和不良预后密切相关，表明其作为临床治疗靶点和预后预测的有前途的独立危险因素的潜力。
