Ohel G, Schwartz Z, Birkenfeld A, Anteby S O, Schenker J G
Arch Gynecol. 1986;239(2):75-80. doi: 10.1007/BF02133966.
Epidemiological data on Israeli patients with second primary genital malignancies associated with endometrial cancer is presented. During the 7 years of study, 29 (2.9%) of 1,007 patients with endometrial cancer had additional primary malignancy involving the genital organs. Of these, there were 25 (2.5%) ovarian and 4 (0.4%) cervical malignancies. The occurrence of a second malignancy was related to ethnic origin. The ratio of European/American to Asian/African Jewish descendants was 8.7 to 1. A significantly greater than expected incidence of ovarian and cervical malignancy was detected in the endometrial cancer patient (P less than 0.0001). The prognosis was mainly influenced by the clinical staging of disease at the time of diagnosis. Recognition of the fact that second primary cancers occur at a higher than expected frequency in patients with endometrial cancer, offers an opportunity for their early detection.
本文呈现了以色列患有与子宫内膜癌相关的第二原发性生殖器恶性肿瘤患者的流行病学数据。在7年的研究期间，1007例子宫内膜癌患者中有29例（2.9%）发生了累及生殖器官的额外原发性恶性肿瘤。其中，有25例（2.5%）为卵巢恶性肿瘤，4例（约0.4%）为宫颈恶性肿瘤。第二原发性恶性肿瘤的发生与种族起源有关。欧美犹太后裔与亚非犹太后裔的比例为8.7比1。在子宫内膜癌患者中，检测到卵巢和宫颈恶性肿瘤的发病率显著高于预期（P小于0.0001）。预后主要受诊断时疾病临床分期的影响。认识到子宫内膜癌患者中第二原发性癌症的发生频率高于预期这一事实，为早期检测提供了机会。
