Schwartz Z, Ohel G, Birkenfeld A, Anteby S O, Schenker J G
Gynecol Oncol. 1985 Sep;22(1):40-5. doi: 10.1016/0090-8258(85)90005-8.
An epidemiologic study of multiple primary malignant neoplasms in endometrial cancer patients in Israel is presented. During the 7-year period of the study, 104 patients (10.3%) out of 1007 patients diagnosed as having endometrial cancer had another primary cancer. There was a significant difference in the incidence of multiple primary cancers between various ethnic groups, women of European/American origin having higher incidence than women of Asian/African origin. A significantly higher than expected incidence of second primary cancers occurred at the following sites: breast (relative risk, 4.1), ovary (relative risk, 11.6), cervix (relative risk, 5.1), and colon (relative risk, 5.9). The prognosis was mainly influenced by the site of the second primary cancer. The increased incidence of multiple primary malignancies justifies a high level of alertness to the possibility of second primary cancer in endometrial cancer patients.
本文呈现了一项针对以色列子宫内膜癌患者多发性原发性恶性肿瘤的流行病学研究。在为期7年的研究期间，1007例被诊断患有子宫内膜癌的患者中有104例（10.3%）患有另一种原发性癌症。不同种族之间多发性原发性癌症的发病率存在显著差异，欧洲/美洲裔女性的发病率高于亚洲/非洲裔女性。以下部位发生第二原发性癌症的发病率显著高于预期：乳腺（相对风险，4.1）、卵巢（相对风险，11.6）、子宫颈（相对风险，5.1）和结肠（相对风险，5.9）。预后主要受第二原发性癌症部位的影响。多发性原发性恶性肿瘤发病率的增加表明，应对子宫内膜癌患者发生第二原发性癌症的可能性保持高度警惕。
