Miao Chenxin, Li Xiaoning, Zhang Yishu
Second Clinical Medical School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Department of Acupuncture, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
Front Neurol. 2023 Sep 14;14:1248348. doi: 10.3389/fneur.2023.1248348. eCollection 2023.
In recent years, the understanding of the mechanisms of acupuncture in the treatment of neurological disorders has deepened, and considerable progress has been made in basic and clinical research on acupuncture, but the relationship between acupuncture treatment mechanisms and brain-derived neurotrophic factor (BDNF) has not yet been elucidated. A wealth of evidence has shown that acupuncture exhibits a dual regulatory function of activating or inhibiting different BDNF pathways. This review focuses on recent research advances on the effect of acupuncture on BDNF and downstream signaling pathways in several neurological disorders. Firstly, the signaling pathways of BDNF and its function in regulating plasticity are outlined. Furthermore, this review discusses explicitly the regulation of BDNF by acupuncture in several nervous system diseases, including neuropathic pain, Parkinson's disease, cerebral ischemia, depression, spinal cord injury, and other diseases. The underlying mechanisms of BDNF regulation by acupuncture are also discussed. This review aims to improve the theoretical system of the mechanism of acupuncture action through further elucidation of the mechanism of acupuncture modulation of BDNF in the treatment of neurological diseases and to provide evidence to support the wide application of acupuncture in clinical practice.
近年来，对针刺治疗神经系统疾病机制的认识不断深入，针刺的基础与临床研究取得了长足进展，但针刺治疗机制与脑源性神经营养因子（BDNF）之间的关系尚未阐明。大量证据表明，针刺对不同的BDNF通路具有激活或抑制的双重调节作用。本综述聚焦于针刺对几种神经系统疾病中BDNF及其下游信号通路影响的最新研究进展。首先，概述了BDNF的信号通路及其在调节可塑性方面的作用。此外，本综述明确讨论了针刺在几种神经系统疾病中对BDNF的调节作用，包括神经性疼痛、帕金森病、脑缺血、抑郁症、脊髓损伤等疾病。还讨论了针刺调节BDNF的潜在机制。本综述旨在通过进一步阐明针刺在治疗神经系统疾病中调节BDNF的机制，完善针刺作用机制的理论体系，并为针刺在临床实践中的广泛应用提供依据。
