Lushington Ryan, Camilli Samuel, Pascual Francisco, Lockey Richard F, Kolliputi Narasaiah
Division of Allergy and Immunology, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa.
J Allergy Clin Immunol Glob. 2023 Feb 8;2(2):100082. doi: 10.1016/j.jacig.2023.100082. eCollection 2023 May.
Nonsteroidal anti-inflammatory drugs alleviate pain and inflammation by inhibiting the cyclooxygenase pathway. This pathway has various downstream effects, some of which are beneficial. Prostaglandin E is a key downstream product in the cyclooxygenase pathway that modulates inflammation. A correlation between aging and increased expression of the prostaglandin E receptor, EP2, has been associated with inflammatory processes, cognitive aging, angiogenesis, and tumorigenesis. Therefore, inhibition of EP2 could lead to therapeutic effects and be more selective than inhibiting cyclooxygenase-2. Studies suggest that inhibition of EP2 restores age-associated spatial memory deficits and synaptic proteins and impairs tumorigenesis. The data indicate that EP2 signaling is important in myeloid cell metabolism and support its candidacy as a therapeutic target.
非甾体抗炎药通过抑制环氧化酶途径减轻疼痛和炎症。该途径具有多种下游效应，其中一些是有益的。前列腺素E是环氧化酶途径中调节炎症的关键下游产物。衰老与前列腺素E受体EP2表达增加之间的相关性与炎症过程、认知衰老、血管生成和肿瘤发生有关。因此，抑制EP2可能产生治疗效果，并且比抑制环氧化酶-2更具选择性。研究表明，抑制EP2可恢复与年龄相关的空间记忆缺陷和突触蛋白，并损害肿瘤发生。数据表明，EP2信号在髓样细胞代谢中很重要，并支持其作为治疗靶点的候选资格。
