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一篇综述:时间干扰刺激在调节脑功能和行为方面的最新进展

A mini-review: recent advancements in temporal interference stimulation in modulating brain function and behavior.

作者信息

Zhu Zhiqiang, Yin Lijun

机构信息

School of Sport, Shenzhen University, Shenzhen, China.

出版信息

Front Hum Neurosci. 2023 Sep 14;17:1266753. doi: 10.3389/fnhum.2023.1266753. eCollection 2023.

DOI:10.3389/fnhum.2023.1266753
PMID:37780965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10539552/
Abstract

Numerous studies have assessed the effect of Temporal Interference (TI) on human performance. However, a comprehensive literature review has not yet been conducted. Therefore, this review aimed to search PubMed and Web of Science databases for TI-related literature and analyze the findings. We analyzed studies involving preclinical, human, and computer simulations, and then discussed the mechanism and safety of TI. Finally, we identified the gaps and outlined potential future directions. We believe that TI is a promising technology for the treatment of neurological movement disorders, due to its superior focality, steerability, and tolerability compared to traditional electrical stimulation. However, human experiments have yielded fewer and inconsistent results, thus animal and simulation experiments are still required to perfect stimulation protocols for human trials.

摘要

许多研究评估了时间干扰(TI)对人类表现的影响。然而,尚未进行全面的文献综述。因此,本综述旨在检索PubMed和科学网数据库中的TI相关文献并分析研究结果。我们分析了涉及临床前、人体和计算机模拟的研究,然后讨论了TI的机制和安全性。最后,我们确定了差距并概述了潜在的未来方向。我们认为,与传统电刺激相比,TI具有卓越的聚焦性、可操控性和耐受性,是治疗神经运动障碍的一项有前景的技术。然而,人体实验产生的结果较少且不一致,因此仍需要动物和模拟实验来完善用于人体试验的刺激方案。

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本文引用的文献

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Front Neuroanat. 2023 Mar 13;17:1128193. doi: 10.3389/fnana.2023.1128193. eCollection 2023.
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Magnetic temporal interference for noninvasive and focal brain stimulation.用于无创和局灶性脑刺激的磁颞干扰。
J Neural Eng. 2023 Jan 18;20(1). doi: 10.1088/1741-2552/acb015.
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Responses of model cortical neurons to temporal interference stimulation and related transcranial alternating current stimulation modalities.
精神病学中的新型非侵入性脑刺激:揭示经颅超声刺激和theta爆发刺激用于研究和治疗
Brain Neurosci Adv. 2025 Mar 14;9:23982128251322241. doi: 10.1177/23982128251322241. eCollection 2025 Jan-Dec.
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20 Hz temporal interference stimulation can more effectively enhance motor evoked potentials in the primary motor cortex.20赫兹的颞叶干扰刺激能更有效地增强初级运动皮层的运动诱发电位。
Front Hum Neurosci. 2025 Feb 19;19:1524485. doi: 10.3389/fnhum.2025.1524485. eCollection 2025.
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