Botwinick J, Storandt M, Berg L
Arch Neurol. 1986 Nov;43(11):1124-7. doi: 10.1001/archneur.1986.00520110024008.
Subjects with mild cases of senile dementia of the Alzheimer type (SDAT n = 18) were followed up over four years with 16 behavioral tests given during four test periods. This group was compared with a normal group (n = 30) matched on age (64 to 81 years), sex, and socioeconomic status. Each of the 16 tests reflected significant group differences, with the normal subjects showing little or no decline and the subjects with SDAT showing progressive decline. The test showing the greatest decline over the four years was the logical memory subtest of the Wechsler Memory Scale, and the test showing the least decline was the Wechsler Memory Scale digit span forward subtest. Even the latter test, however, reflected much decline. There were five subjects with SDAT whose dementia remained mild throughout the four-year study. The others progressed to more severe levels. The five subjects performed more ably on each of the 16 tests than those who progressed to more severe levels. In fact, after an initial level of decline, several of the tests showed little or no decline among the five subjects. Four hypotheses are offered in examining the differences between those subjects whose dementia remained mild and those whose dementia did not.
对轻度阿尔茨海默型老年痴呆症患者（SDAT，n = 18）进行了为期四年的随访，在四个测试阶段进行了16项行为测试。将该组与年龄（64至81岁）、性别和社会经济地位相匹配的正常组（n = 30）进行比较。16项测试中的每一项都反映出显著的组间差异，正常受试者几乎没有或没有下降，而SDAT患者则呈渐进性下降。在四年中下降最大的测试是韦氏记忆量表的逻辑记忆子测试，下降最小的测试是韦氏记忆量表顺背数字广度子测试。然而，即使是后一项测试也反映出了很大程度的下降。在为期四年的研究中，有5名SDAT患者的痴呆症一直保持轻度。其他患者则发展到更严重的程度。这5名患者在16项测试中的每项表现都比那些发展到更严重程度的患者更出色。事实上，在最初的下降水平之后，这5名患者中的几项测试几乎没有或没有下降。在研究痴呆症保持轻度的患者和未保持轻度的患者之间的差异时，提出了四个假设。
