Craft S, Zallen G, Baker L D
Department of Psychology, Washington University, St. Louis, MO 63130.
J Clin Exp Neuropsychol. 1992 Mar;14(2):253-67. doi: 10.1080/01688639208402827.
Glucose utilization appears to play a role in memory, and patients with Senile Dementia of the Alzheimer Type (SDAT) show particular abnormalities of the glucose system. The present study examined the effects of glucose administration on memory in subjects with mild SDAT and age-matched controls. SDAT subjects demonstrated greater overall increases in blood glucose levels following glucose administration. Normal subjects whose blood glucose levels returned to near baseline following glucose administration showed facilitated memory performance, whereas SDAT subjects whose blood glucose levels remained elevated showed significant improvement following glucose administration. The results suggest that impaired glucose regulation contributes to memory impairment in SDAT.
葡萄糖利用似乎在记忆中发挥作用，阿尔茨海默型老年痴呆症（SDAT）患者的葡萄糖系统存在特殊异常。本研究考察了葡萄糖给药对轻度SDAT患者及年龄匹配的对照组受试者记忆的影响。SDAT受试者在葡萄糖给药后血糖水平总体升高幅度更大。葡萄糖给药后血糖水平恢复到接近基线的正常受试者记忆表现得到改善，而血糖水平仍保持升高的SDAT受试者在葡萄糖给药后有显著改善。结果表明，葡萄糖调节受损导致SDAT患者出现记忆障碍。
