磁共振指纹成像在多发性硬化症中的应用。
Magnetic resonance fingerprinting in multiple sclerosis.
机构信息
Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, United States.
Department of Radiology, University of Michigan, Michigan, United States.
出版信息
Mult Scler Relat Disord. 2023 Nov;79:105024. doi: 10.1016/j.msard.2023.105024. Epub 2023 Sep 27.
BACKGROUND
In this cross sectional study, we used MRF to investigate tissue properties of normal-appearing white matter, gray matter, and lesions in relapsing remitting MS (n = 21), secondary progressive MS (n = 16) and healthy controls (n = 9). A FISP-based MRF sequence was used for acquisition, imaging time 5 min 15 s. MRF T1 and T2 relaxation times were measured from lesional tissue, normal-appearing frontal white matter, corpus callous, thalamus, and caudate. Differences between healthy controls and MS were examined using ANCOVA adjusted for age and sex. Spearman rank correlations were assessed between T1 and T2 relaxation times and clinical measures.
OBJECTIVES
To examine brain T1 and T2 values using magnetic resonance fingerprinting (MRF) in healthy controls and MS.
METHODS
The subjects included 21 relapsing-remitting (RR) MS, 16 secondary progressive (SP) MS, and 9 age- and sex-matched HC without manifest neurological disease participating in a longitudinal MRI study. A 3T/ FISP-based MRF sequence was acquired. Regions of interest were drawn for lesions and normal appearing white matter. ANCOVA adjusted for age and sex were used to compare the groups with significance set at 0.05.
RESULTS
A step-wise increase in T1 and T2 relaxation times was found between healthy controls, relapsing remitting MS, and secondary progressive MS. Significant differences were found in T1 and T2 between MS and healthy controls in the frontal normal-appearing white matter, corpus callosum, and thalamus (p < 0.04 for all). Significant differences in T1 and T2 between RR and SPMS were found in the frontal normal-appearing white matter and T2 lesions (p < 0.02 for all). T1 relaxation from the frontal normal-appearing white matter correlated with the Expanded Disability Status Scale [ρ = 0.62, p < 0.001], timed 25 foot walk (ρ = 0.45, p = 0.01), 9 hole peg test (ρ = 0.62, p < 0.001), and paced auditory serial addition test (ρ = -0.4, p = 0.01).
CONCLUSION
These results suggest that MRF may be a clinically feasible quantitative approach for characterizing tissue damage in MS.
背景
在这项横断面研究中，我们使用 MRF 来研究复发缓解型多发性硬化症（RRMS，n=21）、继发进展型多发性硬化症（SPMS，n=16）和健康对照组（n=9）中正常表现的白质、灰质和病变的组织特性。使用基于 FISP 的 MRF 序列进行采集，成像时间为 5 分 15 秒。从病变组织、正常表现的额白质、胼胝体、丘脑和尾状核测量 MRF T1 和 T2 弛豫时间。使用调整年龄和性别的协方差分析（ANCOVA）来检验健康对照组和 MS 之间的差异。使用 Spearman 秩相关评估 T1 和 T2 弛豫时间与临床测量之间的相关性。
目的
使用磁共振指纹图谱（MRF）检查健康对照组和 MS 患者的脑 T1 和 T2 值。
方法
本研究纳入了 21 例 RRMS、16 例 SPMS 和 9 名年龄和性别匹配的无明显神经疾病的 HC，他们参加了一项纵向 MRI 研究。采集了 3T/FISP 基于 MRF 的序列。为病变和正常表现的白质绘制感兴趣区。使用调整年龄和性别的协方差分析（ANCOVA）来比较各组，以 0.05 为显著性水平。
结果
在健康对照组、RRMS 和 SPMS 之间，T1 和 T2 弛豫时间呈逐步增加。在额白质、胼胝体和丘脑的正常表现中，MS 与健康对照组之间的 T1 和 T2 存在显著差异（所有 p<0.04）。在 RRMS 和 SPMS 之间的额白质正常表现和 T2 病变中，T1 和 T2 存在显著差异（所有 p<0.02）。额白质正常表现的 T1 弛豫与扩展残疾状况量表（EDSS）[ρ=0.62，p<0.001]、定时 25 英尺步行（ρ=0.45，p=0.01）、9 孔钉测试（ρ=0.62，p<0.001）和听觉连续加法测试（ρ=0.4，p=0.01）呈正相关。
结论
这些结果表明，MRF 可能是一种可行的临床定量方法，用于表征 MS 中的组织损伤。
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