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SARS-CoV-2 直接感染人诱导多能干细胞衍生的 3D 心脏类器官可再现 COVID-19 心肌炎。

Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis.

机构信息

Department of Cardiovascular Disease, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.

Yunnan Key Laboratory of Biodiversity Information, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, China.

出版信息

Virol Sin. 2023 Dec;38(6):971-974. doi: 10.1016/j.virs.2023.09.005. Epub 2023 Sep 30.

DOI:10.1016/j.virs.2023.09.005
PMID:37783340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10786654/
Abstract

• Establishment of 3D cardiac organoids composed of cardiomyocyte and endothelial layers. • SARS-CoV-2 infection causes multi-lineage cardiac injuries. • Cardiovascular health should be greatly concerned in COVID-19 patients.

摘要

• 构建由心肌细胞和内皮细胞组成的 3D 心脏类器官。

• SARS-CoV-2 感染导致多谱系心脏损伤。

• COVID-19 患者应高度关注心血管健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/47d40a1c635c/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/401e772928d0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/858476054e49/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/7b38cda34337/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/ca6af8adf6e5/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/47d40a1c635c/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/401e772928d0/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/858476054e49/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/7b38cda34337/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/ca6af8adf6e5/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5725/10786654/47d40a1c635c/figs4.jpg

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Long-term cardiovascular outcomes of COVID-19.COVID-19 长期心血管后果。
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