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2018-2020 年法国西南部 HIV 感染者生活质量较差的相关因素（ANRS CO3 AQUIVIH-NA 队列：QuAliV 研究）。

Factors associated with poorer quality of life in people living with HIV in southwestern France in 2018-2020 (ANRS CO3 AQUIVIH-NA cohort: QuAliV study).

机构信息

Univ. Bordeaux, INSERM, BPH, U1219, 33000, Bordeaux, France.

CHU de Bordeaux, Service de Médecine Interne et Maladies Infectieuses, Hôpital Saint-André, 33000, Bordeaux, France.

出版信息

Sci Rep. 2023 Oct 2;13(1):16535. doi: 10.1038/s41598-023-43434-x.

DOI:10.1038/s41598-023-43434-x
PMID:37783722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10545822/
Abstract

We evaluated people living with Human Immunodeficiency Virus' (PLWH) quality of life (QoL) and assessed whether their demographic, disease-related, socioeconomic, or behavioral characteristics were associated with poorer QoL. ANRS CO3 AQUIVIH-NA cohort participants (Nouvelle Aquitaine, France) were recruited to a cross-sectional study (2018-2020) and their QoL assessed (WHOQOL-BREF). We calculated median (Q1, Q3) QoL domain scores and assessed factors associated with poorer median QoL using bivariable and multivariable quartile regression. Of the 965 PLWH included, 98.4% were on antiretroviral therapy, 94.7% were virally-suppressed, 63.5% reported good/very good QoL. Median scores (0-100) were highest for physical (69;Q1, Q3: 56, 81) and environmental (69; 56, 75) QoL and lowest for social (56; 44, 69) and psychological (56; 44, 69) QoL. PLWH with ≥ 3 comorbidities, HIV-related stigma, or income of < 1500€/month had poorer median adjusted physical, psychological, social, and environmental QoL scores compared to reference groups. While more than half of PLWH reported good/very good QoL, we have not achieved good QoL in 90% of PLWH. Multi-morbidity, HIV-related stigma, and social determinants were consistently and independently associated with poorer QoL. Addressing structural factors in addition to those indirectly related to HIV is required to attain good QoL in all PLWH.

摘要

我们评估了人类免疫缺陷病毒（HIV）感染者（PLWH）的生活质量（QoL），并评估了他们的人口统计学、疾病相关、社会经济或行为特征是否与较差的 QoL 相关。ANRS CO3 AQUIVIH-NA 队列参与者（法国新阿基坦）被招募参加一项横断面研究（2018-2020 年），并评估了他们的生活质量（WHOQOL-BREF）。我们计算了 QoL 域得分的中位数（Q1，Q3），并使用双变量和多变量四分位回归评估了与较差中位数 QoL 相关的因素。在纳入的 965 名 PLWH 中，98.4%接受了抗逆转录病毒治疗，94.7%病毒得到抑制，63.5%报告了良好/非常好的 QoL。中位数评分（0-100）最高的是生理（69；Q1，Q3：56，81）和环境（69；56，75）QoL，最低的是社会（56；44，69）和心理（56；44，69）QoL。与参考组相比，患有≥3 种合并症、与 HIV 相关的耻辱感或收入<1500 欧元/月的 PLWH 的调整后生理、心理、社会和环境 QoL 中位数评分较差。尽管超过一半的 PLWH 报告了良好/非常好的 QoL，但我们仍未使 90%的 PLWH 达到良好的 QoL。多种合并症、与 HIV 相关的耻辱感和社会决定因素与较差的 QoL 始终相关且独立相关。除了与 HIV 间接相关的因素外，还需要解决结构性因素，以使所有 PLWH 达到良好的 QoL。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/30c4aaa559ce/41598_2023_43434_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/ea4a38d70cad/41598_2023_43434_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/f480418e70bd/41598_2023_43434_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/ec5cb14ba94b/41598_2023_43434_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/30c4aaa559ce/41598_2023_43434_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/ea4a38d70cad/41598_2023_43434_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/f480418e70bd/41598_2023_43434_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/ec5cb14ba94b/41598_2023_43434_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3293/10545822/30c4aaa559ce/41598_2023_43434_Fig4_HTML.jpg

相似文献

[1]
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本文引用的文献

[1]
Defining multimorbidity in people with HIV - what matters most?

Curr Opin HIV AIDS. 2023-3-1

[2]
A comprehensive analysis of excess depressive disorder in women and men living with HIV in France compared to the general population.

Sci Rep. 2022-4-16

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Quality of life among people living with HIV in England and the Netherlands: a population-based study.

Lancet Reg Health Eur. 2021-7-19

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Quality of life in people living with HIV in Romania and Spain.

BMC Infect Dis. 2021-9-13

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Assessing the psychometric properties of the French WHOQOL-HIV BREF within the ANRS CO3 Aquitaine Cohort's QuAliV ancillary study.

Health Qual Life Outcomes. 2020-7-10

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Stigma reduction interventions in people living with HIV to improve health-related quality of life.

Lancet HIV. 2019-11-24

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Integrating Electronic Patient-Reported Outcome Measures into Routine HIV Care and the ANRS CO3 Aquitaine Cohort's Data Capture and Visualization System (QuAliV): Protocol for a Formative Research Study.

JMIR Res Protoc. 2018-6-7

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Examining the associations between HIV-related stigma and health outcomes in people living with HIV/AIDS: a series of meta-analyses.

BMJ Open. 2016-7-13

[9]
Beyond viral suppression of HIV - the new quality of life frontier.

BMC Med. 2016-6-22

[10]
Health-related quality-of-life of people with HIV in the era of combination antiretroviral treatment: a cross-sectional comparison with the general population.

Lancet HIV. 2014-9-22

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