皮质下动脉硬化性脑病的 P2 波潜伏期延迟闪光视觉诱发电位的探索性研究。
An exploratory study of delayed flash visual evoked potential P2 wave latency in subcortical arteriosclerotic encephalopathy.
机构信息
Department of Encephalopathy, Nanjing Jiangning Hospital of Traditional Chinese Medicine, Nanjing, 211100, China.
Department of Neurology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
出版信息
BMC Neurol. 2023 Oct 2;23(1):345. doi: 10.1186/s12883-023-03388-z.
BACKGROUND
Patients with cognitive dysfunction may present with significantly prolonged the P2 wave latency of flash visual evoked potential. However, no studies have been reported on whether the P2 wave latency of flash visual evoked potential is prolonged in patients with subcortical arteriosclerotic encephalopathy (SAE).
OBJECTIVE
To examine the relationship between flash visual evoked potential P2 wave latency (FVEP-P2 wave latency) and cognitive impairment in patients with SAE.
METHODS
Overall, we recruited 38 SAE patients as the observation cohort (OC) and 34 healthy volunteers as the control cohort (CC). We measured the FVEP-P2 wave latency for both groups. The SAE patients' cognitive abilities were evaluated via mini-mental state examination (MMSE) and the association between the latency of FVEP-P2 and MMSE score was explored by Pearsons´s correlation test.
RESULTS
There is no significant difference between OC (21 males and 17 females; 68.6 ± 6.7 years of age and 9.6 ± 2.8 years of education) and CC (19 males and 15 females; 65.3 ± 5.9 years of age and 10.1 ± 2.6 years of education) in gender and age composition and education level. The FVEP-P2 wave latency of the CC group was (108.80 ± 16.70) ms and the OC FVEP-P2 wave latency was (152.31 ± 20.70) ms. The OC FVEP-P2 wave latency was significantly longer than the CC (P < 0.05). In terms of MMSE scores, the MMSE scores of CC was (28.41 ± 2.34), and that of OC was (9.08 ± 4.39). Compared to the CC, the OC MMSE score was significantly lower (P < 0.05). In addition, the FVEP-P2 wave latency was inversely related to the MMSE (r = -0.4465, P < 0.05) in SAE patients.
CONCLUSION
The FVEP-P2 wave latency wave latency was significantly prolonged in SAE patients and strongly associated with the degree of cognitive dysfunction.
背景
认知功能障碍患者的闪光视觉诱发电位 P2 波潜伏期明显延长。然而，目前尚无研究报道皮质下动脉硬化性脑病（SAE）患者的闪光视觉诱发电位 P2 波潜伏期是否延长。
目的
探讨闪光视觉诱发电位 P2 波潜伏期（FVEP-P2 波潜伏期）与 SAE 患者认知障碍的关系。
方法
共纳入 38 例 SAE 患者为观察组（OC），34 例健康志愿者为对照组（CC）。测量两组 FVEP-P2 波潜伏期。采用简易精神状态检查量表（MMSE）评估 SAE 患者的认知能力，采用 Pearson 相关检验探讨 FVEP-P2 潜伏期与 MMSE 评分的相关性。
结果
OC 组（男 21 例，女 17 例；年龄 68.6±6.7 岁，受教育年限 9.6±2.8 年）与 CC 组（男 19 例，女 15 例；年龄 65.3±5.9 岁，受教育年限 10.1±2.6 年）在性别、年龄构成和受教育程度方面无显著差异。CC 组 FVEP-P2 波潜伏期为（108.80±16.70）ms，OC 组 FVEP-P2 波潜伏期为（152.31±20.70）ms。OC 的 FVEP-P2 波潜伏期明显长于 CC（P<0.05）。CC 的 MMSE 评分为（28.41±2.34），OC 的 MMSE 评分为（9.08±4.39）。与 CC 相比，OC 的 MMSE 评分明显降低（P<0.05）。此外，在 SAE 患者中，FVEP-P2 波潜伏期与 MMSE 呈负相关（r=-0.4465，P<0.05）。
结论
SAE 患者的 FVEP-P2 波潜伏期明显延长，与认知功能障碍程度密切相关。
Zotero 插件