Przewlocki G, Audibert F, Jolivet M, Chedid L, Kent S B, Neurath A R
Biochem Biophys Res Commun. 1986 Oct 30;140(2):557-64. doi: 10.1016/0006-291x(86)90768-0.
The influence of Murabutide, a muramyl peptide analog, on the response of mice to two synthetic hepatitis B virus antigens was compared with the activity of Al (OH)3 and of FCA. The synthetic peptides represented fragments either of the major component of the hepatitis B surface antigen (HBsAg) or of the pre-S region. They were used either conjugated to toxoid carrier or as a totally synthetic preparation, i.e. copolymerized with a streptococcal peptide. Our results demonstrated that treatment with Murabutide increased the levels of antibodies, modulated their specificity and allowed a better recognition of the natural antigens.
将一种胞壁酰肽类似物——胞壁酰三肽（Murabutide）对小鼠对两种合成乙型肝炎病毒抗原的反应的影响，与氢氧化铝和弗氏完全佐剂（FCA）的活性进行了比较。合成肽代表乙型肝炎表面抗原（HBsAg）主要成分或前S区的片段。它们要么与类毒素载体偶联使用，要么作为完全合成制剂使用，即与链球菌肽共聚。我们的结果表明，用胞壁酰三肽治疗可提高抗体水平，调节其特异性，并能更好地识别天然抗原。
