Cohen M B, Gailey R A, McCoy G C
Am J Emerg Med. 1986 Nov;4(6):552-3. doi: 10.1016/S0735-6757(86)80018-3.
A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and blood pressure followed administration of 1 mg of atropine sulfate. Atropine appears to be useful in treating cases of baclofen overdose complicated by bradycardia and hypotension.
