Ferner R E
Postgrad Med J. 1981 Sep;57(671):580-1. doi: 10.1136/pgmj.57.671.580.
A healthy 17-year-old girl took a single large dose (420 mg) of baclofen. She was conscious on admission to hospital, but within 3.5 hr of overdose showed signs of marked cerebral, cardiac and respiratory depression, flaccidity and hypothermia. Eight hours after overdose, atropine administered i.v. produced a worth-while increase in cardiac output, ventilation and temperature, lasting for about 90 min. This is of therapeutic and theoretical interest, and supports the veiw that baclofen leads to cholinergic dominance.
一名17岁健康女孩单次服用了大剂量（420毫克）的巴氯芬。入院时她意识清醒，但服药过量3.5小时内就出现了明显的脑、心脏和呼吸抑制、肌肉松弛及体温过低的症状。服药过量8小时后，静脉注射阿托品使心输出量、通气量和体温显著增加，持续约90分钟。这具有治疗和理论意义，并支持巴氯芬导致胆碱能占优势的观点。
