Mia Md Abdur Rashid, Dey Dipta, Sakib Musfiqur Rahman, Biswas Md Yeaman, Prottay Abdullah Al Shamsh, Paul Niloy, Rimti Fahmida Hoque, Abdullah Yusuf, Biswas Partha, Iftehimul Md, Paul Priyanka, Sarkar Chandan, El-Nashar Heba A S, El-Shazly Mohamed, Islam Muhammad Torequl
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalgonj, Bangladesh.
Phytother Res. 2023 Dec;37(12):5724-5754. doi: 10.1002/ptr.8017. Epub 2023 Oct 2.
Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number of PCa patients continues to rise despite the availability of effective treatments in recent decades. The current therapy with chemotherapeutic drugs has been largely ineffective due to multidrug resistance and the conventional treatment has restricted drug accessibility to malignant tissues, necessitating a higher dosage resulting in increased cytotoxicity. Plant-derived bioactive compounds have recently attracted a great deal of attention in the field of PCa treatment due to their potent effects on several molecular targets and synergistic effects with anti-PCa drugs. This review emphasizes the molecular mechanism of phytochemicals on PCa cells, the synergistic effects of compound-drug interactions, and stem cell targeting for PCa treatment. Some potential compounds, such as curcumin, phenethyl-isothiocyanate, fisetin, baicalein, berberine, lutein, and many others, exert an anti-PCa effect via inhibiting proliferation, metastasis, cell cycle progression, and normal apoptosis pathways. In addition, multiple studies have demonstrated that the isolated natural compounds: d-limonene, paeonol, lanreotide, artesunate, and bicalutamide have potential synergistic effects. Further, a significant number of natural compounds effectively target PCa stem cells. However, further high-quality studies are needed to firmly establish the clinical efficacy of these phytochemicals against PCa.
在全球范围内，前列腺癌（PCa）被视为一个具有挑战性的健康问题，尽管近几十年来已有有效的治疗方法，但PCa患者的数量仍在持续上升。由于多药耐药性，目前使用化疗药物的治疗方法在很大程度上无效，而且传统治疗限制了药物对恶性组织的可及性，需要更高的剂量，从而导致细胞毒性增加。植物来源的生物活性化合物由于其对多个分子靶点的强大作用以及与抗PCa药物的协同作用，最近在PCa治疗领域引起了广泛关注。本综述强调了植物化学物质对PCa细胞的分子机制、化合物 - 药物相互作用的协同效应以及针对PCa治疗的干细胞靶向作用。一些潜在的化合物，如姜黄素、苯乙基异硫氰酸酯、非瑟酮、黄芩素、黄连素、叶黄素等，通过抑制增殖、转移、细胞周期进程和正常凋亡途径发挥抗PCa作用。此外，多项研究表明，分离出的天然化合物：d - 柠檬烯、丹皮酚、兰瑞肽、青蒿琥酯和比卡鲁胺具有潜在的协同效应。此外，大量天然化合物可有效靶向PCa干细胞。然而，需要进一步的高质量研究来坚定地确立这些植物化学物质对PCa的临床疗效。
