阿尔茨海默病与胃肠道微生物群关系的研究进展

Advances in the study of the relationship between Alzheimer's disease and the gastrointestinal microbiome.

作者信息

Li Xin-Yan, Qin Hao-Yue, Li Ting-Ting

机构信息

Southwest Medical University Luzhou Sichuan China.

Department of Anesthesiology, Institute of Neurological Disease, West China Hospital Sichuan University Chengdu China.

出版信息

Ibrain. 2022 Sep 8;8(4):465-475. doi: 10.1002/ibra.12065. eCollection 2022 Winter.

DOI:10.1002/ibra.12065

PMID:37786585

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10528962/

Abstract

There are many trillions of bacteria in the gastrointestinal microbiome (GM). Their ecological dysregulation can contribute to the development of certain neurodegenerative diseases, including Alzheimer's disease (AD). AD is common dementia and its incidence is increasing year by year. However, the relationship between GM and AD is unclear. Therefore, this review discusses the relationship between GM and AD, elaborates on the possible factors that can affect this relationship through the inflammation of the brain induced by blood-brain damage and accumulation of amyloid deposit, and proposes feasible ways to treat AD through GM-related substances, such as probiotics, Mega-3, and gut hormones, including their shortcomings as well.

摘要

胃肠道微生物群（GM）中存在数万亿计的细菌。它们的生态失调会促使某些神经退行性疾病的发展，包括阿尔茨海默病（AD）。AD是常见的痴呆症，其发病率逐年上升。然而，GM与AD之间的关系尚不清楚。因此，本综述讨论了GM与AD之间的关系，阐述了可能通过血脑损伤和淀粉样蛋白沉积诱导的脑部炎症影响这种关系的因素，并提出了通过与GM相关的物质（如益生菌、ω-3脂肪酸和肠道激素）治疗AD的可行方法，同时也包括它们的缺点。