Zhang Ling-Jing, Zhou Hong-Su, Wang Shi-Ya, Guan Yi-Huan, Zhang Chao, Fang De-Rong
Department of Anesthesia Zunyi Medical University Zunyi Guizhou China.
Department of Anesthesia Graduate School of Zunyi Medical University Zunyi Guizhou China.
Ibrain. 2022 May 22;8(2):227-240. doi: 10.1002/ibra.12037. eCollection 2022 Summer.
Microglia are the main immune cells in the brain and the first defense barrier of the nervous system. Microglia play a complex role in the process of stroke. A growing number of studies focus on the mechanism of action of drugs functions and how to regulate microglia. Therefore, we talk about the pathophysiological mechanisms of stroke and elaborate on the microglia signaling pathways of drug action in stroke models and how these drugs play a role in stroke treatment in this review. Understanding how drugs modulate proinflammatory and anti-inflammatory responses of microglia may be critical to implementing therapeutic strategies using immune interventions in stroke.
小胶质细胞是大脑中的主要免疫细胞，也是神经系统的第一道防御屏障。小胶质细胞在中风过程中发挥着复杂的作用。越来越多的研究聚焦于药物作用机制以及如何调节小胶质细胞。因此，在本综述中，我们将探讨中风的病理生理机制，阐述中风模型中药物作用的小胶质细胞信号通路，以及这些药物如何在中风治疗中发挥作用。了解药物如何调节小胶质细胞的促炎和抗炎反应，对于在中风中实施免疫干预治疗策略可能至关重要。
