Zivković Sladana, Velicković Ljubinka, Kostov Milos, Stojanović Nebojsa
Vojna bolnica, Odsek za urologiju, Nis.
Vojnosanit Pregl. 2003 Jul-Aug;60(4):449-54. doi: 10.2298/vsp0304449z.
The prostatic adenocarcinoma is one of the most frequent malignant tumors of men over 50 years of age. It is distinguished by aggressive clinical course and heterogeneous multifocal histomorphologic changes. PSA is the most reliable serum marker in diagnostics and observation of prostatic carcinoma, and Gleason's system of tumor-diferentiation grading is generally accepted way of determining the histologic grade. Gleason's system is correlated with serum levels of PSA and with biological behaviour of the tumor. We presented 40 patients with verified ACP in whom the level of serum PSA, Gleason's grade and score were compared. Highly significant correlation was found between serum level of PSA and the differentiation grade of the tumor--Gleason's grade and score. Combination of PSA parameters and Gleason's score enables correct estimation of tumor's behaviour and correct therapeutic protocol.
前列腺腺癌是50岁以上男性中最常见的恶性肿瘤之一。其特点是临床病程侵袭性强，组织形态学变化多灶性且异质性。前列腺特异性抗原（PSA）是前列腺癌诊断和观察中最可靠的血清标志物，而 Gleason肿瘤分化分级系统是确定组织学分级的普遍认可方法。Gleason系统与PSA血清水平及肿瘤生物学行为相关。我们报告了40例经证实患有前列腺腺癌的患者，对其血清PSA水平、Gleason分级和评分进行了比较。发现血清PSA水平与肿瘤分化分级——Gleason分级和评分之间存在高度显著相关性。PSA参数与Gleason评分相结合能够正确评估肿瘤行为并制定正确的治疗方案。
