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对近 8000 个基因组的基因组分析揭示了中国抗生素耐药性的驱动因素和全景。

Genomic analysis of almost 8,000 genomes reveals drivers and landscape of antimicrobial resistance in China.

机构信息

International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University , Zhengzhou, Henan, China.

CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS) , Beijing, China.

出版信息

Microbiol Spectr. 2023 Dec 12;11(6):e0208023. doi: 10.1128/spectrum.02080-23. Epub 2023 Oct 3.

DOI:10.1128/spectrum.02080-23
PMID:37787535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10714754/
Abstract

We established the largest Salmonella genome database from China and presented the landscape and spatiotemporal dynamics of antimicrobial resistance genes. We also found that economic, climatic, and social factors can drive the rise of antimicrobial resistance. The Chinese local Salmonella genome database version 2 was released as an open-access database (https://nmdc.cn/clsgdbv2) and thus can assist surveillance studies across the globe. This database will help inform interventions for AMR, food safety, and public health.

摘要

我们建立了中国最大的沙门氏菌基因组数据库，并展示了抗微生物药物耐药性基因的状况和时空动态。我们还发现，经济、气候和社会因素可以推动抗微生物药物耐药性的出现。中国地方沙门氏菌基因组数据库版本 2 作为一个开放获取的数据库发布（https://nmdc.cn/clsgdbv2），因此可以协助全球的监测研究。该数据库将有助于对抗微生物药物耐药性、食品安全和公共卫生干预措施提供信息支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/37433663da90/spectrum.02080-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/c383d20280e7/spectrum.02080-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/73af9ba2baa1/spectrum.02080-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/5cc3693a25ab/spectrum.02080-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/551a44f2b5d0/spectrum.02080-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/1d0964ea9f40/spectrum.02080-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/37433663da90/spectrum.02080-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/c383d20280e7/spectrum.02080-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/73af9ba2baa1/spectrum.02080-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/5cc3693a25ab/spectrum.02080-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/551a44f2b5d0/spectrum.02080-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/1d0964ea9f40/spectrum.02080-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c55/10714754/37433663da90/spectrum.02080-23.f006.jpg

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