Gastrointestinal Bacteria Reference Unit (GBRU), UK Health Security Agency, London, UK.
Division of Infection and Immunity, University College London, London, UK.
J Appl Microbiol. 2022 Oct;133(4):2569-2582. doi: 10.1111/jam.15728. Epub 2022 Aug 5.
To compare the antimicrobial resistance (AMR) genes in a genetically diverse group of Salmonella enterica recovered from foods imported into England between 2014 and 2018.
Whole genome sequence was used to detect AMR genes or chromosomal mutations associated with AMR in Salmonella recovered from edible leaves imported from Asia (n = 115) as compared to Salmonella (n = 231) isolated from raw chicken, 74% originated from South America. Among isolates from edible leaves, three (3%) showed resistance to at least one antimicrobial agent, two (2%) of which were multidrug resistant (MDR, resistance to three or more antimicrobial classes). Resistance to at least one antimicrobial agent was detected in 214 (93%) in the chicken isolates, with 164 (71%) showing MDR. Genetic diversity and AMR profiles were highly heterogeneous across the different serovars.
Resistance was rare among the Salmonella isolates from edible leaves but common (including MDR) among those from raw chicken.
Surveillance of AMR in imported foods is essential for monitoring the risk of transmission of resistance from the food chain to humans and provides added public health value to pre-existing controls of the food chain.
比较 2014 年至 2018 年期间从英国进口食品中分离出的具有遗传多样性的沙门氏菌属中抗菌药物耐药（AMR）基因。
使用全基因组序列检测从亚洲进口的可食用叶片中分离出的沙门氏菌（n=115）与从生鸡肉中分离出的沙门氏菌（n=231）中与 AMR 相关的 AMR 基因或染色体突变，74%的生鸡肉来源于南美洲。在可食用叶片分离株中，有 3 株（3%）至少对一种抗菌药物具有耐药性，其中 2 株（2%）为多重耐药（MDR，对三种或更多种抗菌药物类别具有耐药性）。在鸡肉分离株中，有 214 株（93%）至少对一种抗菌药物具有耐药性，其中 164 株（71%）为 MDR。不同血清型的遗传多样性和 AMR 谱高度异质。
可食用叶片中分离出的沙门氏菌属分离株耐药性罕见，但生鸡肉中分离出的沙门氏菌属分离株耐药性常见（包括 MDR）。
对进口食品中 AMR 的监测对于监测从食物链向人类传播耐药性的风险至关重要，并为现有的食物链控制措施提供了额外的公共卫生价值。
